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I know this topic has been discussed before on here, but can’t find the thread. If you wake up early-ish and feel somewhat normal and then go back to sleep for an additional hour or two, do you feel worse after the additional sleep than you did when you initially woke up (like more tired/more...

I think the results from previous trials have been mixed.

Highlights • Stimulants altered functional connectivity in action regions consistent with arousal • Stimulants altered functional connectivity in salience regions consistent with reward • Stimulants did not affect canonical attention networks • Stimulants reversed the behavioral and brain...

Haven’t read but: All Chinese authors All Chinese institutions Not a review article No Traditional Chinese Medicine angle A shape of things to come?

“We treat clinical trials as pass/fail gates. That’s a mistake. Trials are a discovery engine. Clinic-in-the-loop describes how we use early in-human failures as data — exactly how CAR-Ts evolved from setbacks into curative cancer therapies.”

Another article https://press.asimov.com/articles/clinic-loop

I think I may have asked this question somewhere. But are there any immune mediated diseases where a treatment only works on one sex? Also the four or five ? patient Amendment may have included males—we don’t know.

Did he measure total IgG before administering Tecli? NK cells?

"Dr. Koroshetz- head of NINDS/NIH - has always been respectful to me over the years. However, he never went to bat to address the absurdly low funding levels for ME/CFS. From that lens.. there is small chance that his replacement could be worse. Hopefully, it will be better."

Everyone is going to hate me for saying this, but if Habets is going to administer Tecli, he should do normal multiple myeloma dosages, not these low dosages.

Thank you for this report. Sorry it wasn’t successful for you. Just to clarify, you received low dose Tecli? What were your dosages/number of injections. Any CRS? Also Habets is claiming success with this treatment—have you heard of any other of his patients who improved with Tecli? Thanks.

https://www.statnews.com/2025/12/27/nih-neurological-disorders-stroke-institute-director-koroshetz-ousted/ Director of NIH neurological disorders institute is ousted, adding to leadership churn Agency declines to reappoint Walter Koroshetz, who has led NINDS since 2015

Unbelievable. What “leading researchers” did they ask to get this p.o.s. included?

Haven’t read yet. https://ifp.org/proxy-praxis-how-surrogate-endpoints-can-speed-drug-development/ “ In drug development, speed is critical. Each additional year a clinical trial takes can cost hundreds of millions of dollars, due both to ongoing trial expenses and the loss of valuable market...

Dr. Steven Alberts, MD Can you please remind us again that you are a physician?

I’ll just say that if ME/CFS is an immune-mediated diseases like a variant of an autoimmune disease, then it should be relatively easy to treat since there are now so many new treatments, especially mab drugs—e.g. Daratumumab. If it is a brain disease like schizophrenia/depression or a...

To make responses more manageable, would be better to ask one question per thread…….

@MelbME

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