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I think this is a secondary analysis from this trial: https://www.s4me.info/threads/individualized-and-controlled-exercise-training-improves-fatigue-and-exercise-capacity-in-patients-with-long-covid-2024-kieffer-et-al.47282/. Or something like it. It's in a reference for the description of the...

When a measure becomes a target, it ceases to be a good measure. Far worse when it's not even a measure, and the whole process of trying to move the target involves explicitly trying to convince participants to report that the target has moved. It's so absurd that the entire process here...

So close to getting it. "The tank is full, and yet it doesn't go as far as when it used to be full before" The ease with which they insult people who make all this effort to participate in their studies is something.

Seems like the most important finding is how natural improvement is common, but we knew that already. The changes in the fluvoxamine are quite small, not nearly enough to overcome the flaws and noise, and the fact that no blinding can withstand the obvious side effects of SSRIs. It's so common...

I have no idea what a 'fatigue memory' means. I have so little memory of anything, I don't need to suppress anything. I don't really understand how an 'anger memory' works either. I can remember being angry at something, vaguely. It won't make me angry, though. I guess it means remembering...

The paper is interesting in that it aptly lists many of the reasons for why fatigue is not taken seriously, and it's quite simple: medicine does not take it seriously. Their solutions involve the same "not taking it seriously" ideas that have always failed, hence repeating the exact same mistake...

Academic citation stonks go up. The clickfluencer economy feeds itself on its own waste.

There is a programming joke: how do programmers copy and paste? ctrl-cccccccccccccccccccccccccc ctrl-v. Sometimes we just smash that ctrl-c because it's annoying when we don't press the key enough and end up pasting something we didn't want. Evidence-based medicine is the opposite, they go...

Almost completely arbitrary, isn't it? From this concept, there is no reason to assume that a cure for a permanent disability won't be found eventually. Whoever 'deems' something can't know either way. Those studies haven't been done precisely because the answer is known. And since none have...

Yup. Even that in most cases barely seems to fit. If being jittery from taking too much caffeine gets called the same, among many other situations, then the whole concept is basically both useless and meaningless. I really doubt much of the current nomenclature in mental health will stand the...

The fact that zero thought is given to the validity of their criteria is truly baffling. It's even worse in context when you consider how incredibly important false positives are in medicine. Not here, they genuinely seem to perceive them as a good thing. The more the merrier. Someone could...

Fatigue? I don't see how. I can't even imagine what psychiatry could possibly even have to do with fatigue, unless it's defined as low motivation, which is usually why it gets miscategorized this way.

At some point, medicine had to choose between "rousing confidence" and honesty, and of course they went with the overconfident BS so now here we are, decades into this choice and, like everything else, medicine is falling apart at the most basic levels. There is a reason why LLMs are overly...

I haven't noticed the problems in drug trials that we see in 'pragmatic' trials, they almost always report honestly. Even when run by psychobehavioralists, though they are biased against them so I don't think it counts for much. If all clinical trials followed the same standards and had the same...

And it really is actually feeding itself with its own output and only getting worse as a result. It's just amazing how all the valid criticism about LLMs applies here 10x. Human slop is so much worse than AI slop.

This is seriously some of the most bizarre stuff happening in the world right now, and I truly understand the full implications of what I'm saying. It really is that absurd. I don't see how things would be any worse if astrology ruled this instead. I'm not sure which age group taken at random...

It's so obvious once you see it, but outside of biomedical research, medicine has almost completely abandoned even the pretense of plausibility. Any dumb thing for any reason in any combination is worth trying, dozens and dozens of identical times, if it's popular enough. And if it's really...

This is the product of decades of "work". It's not something they started doing just recently. This is the most over-tested, over-funded nothing in history, applied onto millions, asserted to be effective, a fact that was always contradicted, by their own studies! And, this, they call...

From The Simpsons "Lisa the vegetarian" episode, when Lisa is mad at Homer for liking eating meat too much, and steals the pig he was roasting during a BBQ: And it's all made even more relevant by the next scene:

If it has simply been an issue of not being informed, it would be bad enough, but the truth is that this was both covered up and the product of genuine incompetence, leading to people being explicitly misinformed about it. This would be equivalent to construction workers having to do work with...