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Rereading the article I get the impression that the author is trying to say something about the importance of mental health while not having a good understanding of things, and bizarrely picking the worst possible illnesses to use as background for this.

This is so common in these articles. They want to say it's psychosomatic, encounter criticism, then redefine their own position into some vague statement about psychological factors that's hard to disagree with even if one has to guess what is actually meant. Obviously sick people do experience...

As far as I know it's not uncommon for SNPs or genes to be associated with multiple distinct illnesses. Some illnesses believed to be distinct have also been recognized as being the same thing thanks to genetics research. In my opinion is the genetic risk factors for a complex illness like...

The thought of being able to find genes/SNPs involved in the disease causation is very exciting.

The odds of reaching the 20000 target seem good now. What does the DecodeME team think?

Edited: It's a letter in response to Ludwig et al.

Digital biomarker? Subclinical depression? waitlist control? Is this an attempt to reach the lowest possible standards? A bit like a dive in the Mariana trench to see how low you can go.

The benefit of spending time in nature is real although I'm not sure if it has any meaningful effect on an illness. In a pine/cypress forest that I got to sometimes, the air takes on a new quality of being fresh. I suspect this effect could be due to antiinflammatory compounds released by the...

Both, but the ones that will also receive funding seem more important. With support from researchers a lot more pressure could be exerted to influence the ME/CFS Lifelines study. For example to enforce the requirement of a clinical diagnosis of ME/CFS by doctors that the patient community can...

We need researchers to weigh in and tell us whether they agree with our concerns, and what they think could be done.

It's the patients that should decide what is disrespectful behaviour towards them and what is not.

And by assumed they mean "we interpret things that way because it creates jobs for us". One could also make very different interpretations.

How disappointing that the effect is so weak.

I have a monoallelic frameshift mutation in the PER1 gene which is part of the the clock machinery that creates circadian rythms in the brain and peripheral tissues. My understanding is that it would not cause the serum to have the effect described here but might further worsen circadian rythms...

A big factor is probably how rested patients are and how long ago the last significant exertion was. We already know that exertion causes significant changes (at least for a few days, maybe more) and if we don't ensure that all study participants are similarly rested it could introduce a lot of...

Language that is intended to mislead readers with little expertise, and obfuscate rather than provide clarity, is so typical of psychosomatics. It works because the average person can't see obvious problems and will trust experts.

From what I understood the liver has its own circadian rythm that is influenced by and influences feeding and fasting behaviour. I learned about this by observing how I could not handle skipping meals around 17:00 but could easily tolerate moving my dinner to 17:00 and not eating afterwards...

TORC1 is described as stress sensor. And it influences autophagy. At least one research group has reported abnormally elevated TORC1 activity, while at least one other group has reported abnormally elevated autophagy. I hope I got things right because I'm going from brain fogged memory. That's...

The pretense that LC is totally new is a way to get research done without upsetting people that are invested in trivializing and psychsomaticizing ME. To some degree, also without upsetting power structures. It would have been better if society had admitted that LC is often probably a form of...