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After Paul Fishers video and paper I found this NIH site on Mitochondrial complex V deficiency interesting https://ghr.nlm.nih.gov/condition/mitochondrial-complex-v-deficiency If I remember right haven't there been some studies showing thickening of the heart wall in ME?

I'm wondering if the team at the ME/CFS Biobank processes blood on site at patients houses, or nearby facility? Karl talked about processing and handling needing to be almost immediate and consistent across "centers" for the type of work he wants to do. For example, in this tweet you can see...

Hi @Ron. I'm wondering how long did it take you to recover and did you receive a report from the Cardiologist? If you got a report do you think the report would be good enough to show loss of function for disability purposes? Having that sort of evidence for no cost might attract more recruits...

Add another "Something in the blood" experiment from Alain Moreau. In his presentation at the Stanford Symposium Alain Moreau described using Jurkat cells (Jurkat cells are an immortalized line of human T lymphocyte cells, I'm guessing you purchase them from a supplier???) with healthy and...

@mariovitali In Alain Moreau's Stanford Symposium presentation he showed this slide where 3 out of 4 twin families showed a mutation in SLC1A2 related to Glutamate clearance in the brain. Glutamate keeps popping up!

I used to take this - Natures Bounty B Complex from Amazon. Vitamin B6 content 5mg, 294% % daily value. I used to take half a pill every other day and that was too much based on blood testing.

According to LabCorp this is the reference range for normal levels Male: 5.3-46.7 µg/L; female: 2.0-32.8 µg/L https://www.labcorp.com/test-menu/36686/vitamin-bsub6-sub-plasma Even a small amount of supplementation every other day took my blood levels above the high level which would be bad for...

This bit in the paper seems an important warning, as there is a lot of advice on ME/CFS out there that suggests supplementing with B-vitamins - high levels of B6 are bad for SFN! Full paper can be accessed here...

Maureen Hanson's keynote talk is still on Facebook, starting at 57mins

~$1.5MM list price without discount

I don't believe that they do. However they have used the same process of analysis in other diseases previously and the mitochondrial dysfunction is different here As @Hutan posted Lymphocyte basal OCR is difficult to measure as the level is approaching the measurement limit of the instrument...

@Jonathan Edwards Have you heard any other researchers notice lymphocytes dying faster in ME patients? This is what @Hutan posted from the paper. If this is the case what would the health implications be of faster recycling of lymphocytes or would this likely be a cell culture effect not seen in...

Just thought I would post this again. Paul Fisher really does an excellent job explaining this work in the video of this thread. Well worth a watch. [Some slides were blacked out pre-publication]. https://www.s4me.info/threads/video...nsatory-changes-in-me-cfs-patient-cells.9177/ Direct link to...

Paul Fisher is quoted in the press release for the Australian Biobank to be funded by the Mason foundation. https://www.eqt.com.au/about-us/media-centre/news-items/whats-new/a-bold-decision-to-back-a-plan-for-a-breakthrough Could this paper possibly describe the meat and potatoes of a...

To learn more about this follow-up study you can watch the video from Paul Fisher to learn about the results of the first study on this thread...

Paper on this work has been released. Thread here https://www.s4me.info/threads/an-isolated-complex-v-inefficiency-and-dysregulated-mitochondrial-function-in-immortalized-lymphocytes-from-me-cfs-patients-missailidis-et-al-2019.11121/ Follow-up study thread here...

This is really exciting on first skim. There are lots of test results with big separation between controls and patients (CCC qualified), with low p numbers. Lots of hard data. Paper was originally presented in this talk...

Good stuff @mariovitali . Can you explain the three groupings in your screenshot - not the results, but what are the groupings showing - Chi Square, Consistency Evaluator, Information Gain.

Don't forget to register for the livestream at the link above for those that want to watch any of the presentations live.

I am really intrigued or should I say puzzled by the ESR results in this paper. Median values ESR (mm/h): PwME(n=272)=7, HC(n=135)=5, P<0.001 This is one of the key findings by the UK ME Biobank team. Yet there have been many anecdotal reports that ESR is often low. Does anyone know of other...