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  1. W

    Coronavirus - worldwide spread and control

    Thanks @Andy . This is really superb. I highly recommend those interested in this thread listen to this. Ian Lipkin was first told about this virus in mid-December and he went to China and met with very senior scientists and Chinese Health/CDC folks. He has a 17 year strong relationship with...
  2. W

    Fecal transplant is not benign

    FDA has just released a warning about fecal transplants and COVID-19. I wonder how this will affect Karl Morten's partnership with the private clinic and also Invest In ME / Norwich research team...
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    Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease (Jan2020) Gate, M.Davis & Wyss-Coray, Stanford)

    Here is a linked nature article that describes the work, and what it may or may not mean. https://www.nature.com/articles/d41586-019-03892-8
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    Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease (Jan2020) Gate, M.Davis & Wyss-Coray, Stanford)

    This paper on Alzheimer’s is interesting because Mark Davis (one of the authors) and team are using similar techniques on ME patients to look for targets for T-Cell expansion. For Alzheimer's they found TCR's responding to two separate Epstein–Barr virus antigens in CSF...
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    The biology of coronavirus COVID-19 - including research and treatments

    The FDA issued approval for "Investigational COVID-19 Convalescent Plasma - Emergency INDs" on March 24th. https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds
  6. W

    The biology of coronavirus COVID-19 - including research and treatments

    There are a lot of posts on s4me about modelling. This project seems interesting. This is the projects website https://covidactnow.org/ You can access the model on google sheets for those folks that are interested...
  7. W

    The biology of coronavirus COVID-19 - including research and treatments

    Here is some thing positive about COVID19. Scientists are coming together to help. Stanford has a list of projects they are working on. https://med.stanford.edu/covid19/research.html Some highlights I selected : The Synder lab where some of the Stanford CFS Research Center team work has...
  8. W

    The biology of coronavirus COVID-19 - including research and treatments

    This is also a nice personal piece about how Stanford is ramping up testing to 1000 tests a day in order to support other local hospitals. It required cooperation from a lot of folks to overcome shortages. California is way behind on testing, with a big backlog, and like other areas patients who...
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    The biology of coronavirus COVID-19 - including research and treatments

    Stanford are one of the centers participating in the Remdesivir trial. According to this CNBC interview with the Stanford Medicine School Dean they are involved with two, one for severe and one for less severe. Here is a Palo Alto Online newspaper report of a patient who participated and...
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    The biology of coronavirus COVID-19 - including research and treatments

    The blood does need to be tested. This is an article about a recent Stanford investigation into other viruses that may be present. They are sharing it early at the request of the California Department of Public Health. https://medium.com/@nigam/higher-co-infection-rates-in-covid19-b24965088333
  11. W

    ABCC6 and pathogenic SNPs

    Please, please, please check OpenSNP and dBSNP for allele and genotype frequency. Cross reference with kaviar frequency and CADD score. Provide links to ClinVar. rs2238472 for example has an allele frequency of 25% (dnSNP) and a genotype frequency of 46%=CT+TT (OpenSNP). This is in line with the...
  12. W

    ABCC6 and pathogenic SNPs

    Some info from NIH site about this gene. https://ghr.nlm.nih.gov/gene/ABCC6#
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    USA: Center for Solutions for ME/CFS - news and updates from Columbia University's NIH funded center, Lipkin

    Short version : No answers yet but trying to map metabolites to symptoms.
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    Antibody for SARS -CoV- 2

    Ian Lipkin talked on TV about a small trial of treatment in China with plasma that has antibodies from recovered patients.
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    The biology of coronavirus COVID-19 - including research and treatments

    According to the article in this tweet posted by Stanford ME researcher Fereshteh Jahanbani, if I understand correctly, the virus was discovered in bats in 2015 and they realised how bad it would be if it spread to humans. Paper : A SARS-like cluster of circulating bat coronaviruses shows...
  16. W

    Blog: Occupy ME: "NIH Funding for ME Needs Life Support"

    NIH doesn’t list a prevalence figure for ME/CFS on it’s spending by disease page, but does for other diseases with high numbers of patients? Would be a good topic for @dave30th to follow up on to increase awareness within NIH. [For those wanting to look it up the disease is listed in the table...
  17. W

    Low-dose naltrexone as a treatment for chronic fatigue syndrome, 2020, Bolton, Chapman, Van Marwijk

    Someone on Facebook posted that the Younger LDN trial that was listed to start in 2016 has been suspended due to low participant turnout. That person posted https://clinicaltrials.gov/ct2/show/NCT02965768 Note : Younger did an LDN trial in Fibromyalgia while at Stanford.
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    UK Genome Wide Association Study (GWAS) project - draft website goes live, feedback sought on recruitment plan, and updates

    Would a partnership with SolveME to use their registry for the purpose of registering for future other studies make more sense. That resolves the issue of who maintains the list long term, and who decides who has access to it. Those resources may not be available long term for the GWAS team (or...
  19. W

    Oxford: MitOX Conference 2020, online, 3-4th Dec 2020

    I'm looking forward to Karl Morten and Bhupesh Prusty meeting up - two out of box thinkers and both on the search for the "something in the blood". Bhupesh Prusty is also collaborating with Robert Naviaux to look for the "fatigue factor" in the ME/CFS blood. Now if only Paul Fisher could...
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