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I believe this section is where a link between HHV6 and a subset of ME patients comes from - presence of sncRNA-U14 From methods section Sure would be nice if someone could replicate the FISH analysis, say from the UK ME biobank samples. No idea what FISH entails, or if it requires fresh blood.

For anyone wanting to learn more, Dr Bhupesh Prusty covered a lot of whats in the paper at the recent CMRC 2020 conference. He talks rather fast, but it does help understanding of the paper.

Yep. The answer to that doesn't really matter at this stage. The question is, can you identify the factor(s) in ME/CFS serum that cause it, could those factors lead to the next clue, and could those factor(s) be unique to ME/CFS. This work leads to more questions and that is what is truly...

And this seems pretty clear to me and my untrained eye. Take cells, put them in CFS or HEALTHY serum, add HSV-1, observe clear difference (- is control sample, + is experimental sample). CFS treated samples clearly have lower HSV-1 RNA compared to HEALTHY, showing the antiviral effect.

There is more data on the interferon-type response here in the supplemental section. https://www.immunohorizons.org/content/immunohorizon/suppl/2020/04/23/4.4.201.DCSupplemental/IH_2000006_Supplemental_Materials_1.pdf

Some of those FY2019 grants listed as new grants were approved in 2018. e.g. Abdullah had a 21 Dec 2018 budget start date. With the lack of transparency it is hard to figure out.

On the counter argument I think it was always going to be tough getting approval in the last round. Leonnard Jason has had a long standing mono award that expired and he was awarded a new 5 year R01 grant to continue the work MAINTENANCE AND INCIDENCE OF ME/CFS FOLLOWING MONO Once that...

So I just learnt something new. The ME/CFS Special Emphasis Panel falls under "Integrative, Functional, and Cognitive Neuroscience IRG – IFCN" group https://public.csr.nih.gov/StudySections/DNDA/IFCN ***Formatted for easier reading

Some info on Cort johnsons blog regarding Ron Davis/Stanford applications According to the NIH site March 2019 is the last ME/CFS panel listed, so maybe these latest applications all went through standard channels....... https://public.csr.nih.gov/StudySections/DNDA/IFCN/CFSSEP Next ME/CFS...

@dave30th It has been a year since you published your interview with Steve Olsen at KP. Are you planning a follow-up to see if there has been any progress?

@dave30th has written a couple of blogs on it. This is a link to the latest. https://www.virology.ws/2019/12/10/trial-by-error-mayo-clinics-crappy-website/ Here is a S4ME thread https://www.s4me.info/threads/david-tuller-trial-by-error-mayo-still-champions-get.5258/ I can't remember if he...

Not going to comment on the conclusions. But can someone with some statistics background comment on why it is valid to draw a straight line in these graphs. So many papers I see like this, where a few extra data points, or removal of a few points, could cause a different slope and hence...

I have a question on a similar vein @Jonathan Edwards @Blizna. What if you are showing a few typical characteristics of Marfan syndrome but not all, and have at least one damaging mutation on FBN1, but no specific related heart issues seen (yet). According to this site FBN1 mutations are...

Interesting. The two miRNA's in males that @Hutan highlights as interesting are miRNA-423-5p and miRNA-4443. Just shows you the power of ignoring the fancy words in a paper and looking at the scatter plot to see what really is interesting! I'm only able to scan the paper quickly too.......Sigh...

Looks like PDF access is free, no paywall, if you click on the PDF symbol I'm not able to read in detail, but I took a look at patient selection section. Wouldn't a key part of the investigation of neuropathic pain be to perform traditional diagnostic methods in parallel to confirm a...

Here is a link for the 2017 version on the Wayback machine. https://web.archive.org/web/20170203200543/https://rarediseases.info.nih.gov/diseases/7121/chronic-fatigue-syndrome The biggest change in the 2020 version seems to be the use of "Myalgic encephalomyelitis/chronic fatigue syndrome" in...

The last new NIH grant approvals for ME in NIH reporter system appeared in January. Of the top of my head Leonnard Jason R01 to extend his study of post IM, and R21 for Abdullah Okay, here are the details MAINTENANCE AND INCIDENCE OF ME/CFS FOLLOWING MONO (Jason) Budget Start Date: 1-JAN-2020...

Update from the James Lab on Twitter

The type of balanced analysis contained in this thread is what we come to Science for ME for. Kudos to @minimus for critiquing this study before many many other people did. Here is one of the first critical reports that I saw on Twitter from Elizabeth Bik on March 21, two days after @minimus...