Search results

Perez et al is most likely the awful INIM/Klimas team 23andMe study where no quality control was done. https://www.frontiersin.org/articles/10.3389/fped.2019.00206/full The new paper has this quote. I don't remember a limit on MAF of 0.1, but perhaps I'm thinking of the supplemental table they...

@Ron on the link you provided it shows that the Lo study was retracted Here is the link to the explanation of retraction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252929/

Perhaps you want to broaden the thread from the "Netherlands" to "Benelux" to include Belgium and Luxembourg? Your Avatar is showing you are in Belgium and I wouldn't want you missing out ;).

The most interesting thing I've seen was from @Hip on PR who highlighted this paper where it is thought hydrogen rich water stimulates ghrelin release in the stomach Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice https://www.nature.com/articles/srep03273 ghrelin is one...

Exact same here. Although I've since migrated from cardigans to hoodies ;). I'm actually grateful for this feature to monitor my activity, rather than a step counter that only counts after the first 16 steps or so like other monitors.

You did very good sir! I don't think rules here allow posters to name users on other forums so I kept it anonymous. Until you revealed yourself. Feel free to include your post on how you interpreted the paper here, if you want to that is, perhaps it will generate further discussion. And...

I hope they are aware that Mestinon is contraindicated in some diseases that could be mistaken as ME/CFS such as slow channel congenital myasthenic syndrome, a genetic disease. https://rarediseases.org/rare-diseases/congenital-myasthenic-syndromes/ It is also the drug implicated in GWI -...

We should all remember treatments can have positive as well as negative outcomes. Will OMF explain the proposed benefit of increasing kynurenine, and what the risks are? We've yet to see ANY convincing data for the metabolic trap, two years after work first started!!! There seems to be a lot of...

A user on PR made a very interesting point I think it's worth repeating. By using a model cell line of A549 cells which are grown in patient or HC serum means means replication of the work is possible. I remember @Jonathan Edwards discussing on the nanoneedle thread after that paper was...

I feel the same way. I'm hoping there might be a few more papers to come, perhaps trying to detect certain antibodies such as the peptide array method of this paper. Maybe they can identify something common among responders. Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis...

I think the step count should be taken with a grain of salt, and referred to as an activity measure. That's okay if you are comparing like with like. The paper describes using SenseWear activity armband. So if you have sufficient arm movement it may count as steps. I've no idea which version of...

Here is @Chris Ponting talk from CMRC 2020 conference on the T cell receptor expansion research described by this thread. First results are expected at the end of 2020. They are testing the null hypothesis in blinded samples that there is no difference detected between the four groups of...

A short update - one paper submitted another in process :)

Can't remember if I posted this or not. What's intriguing about the HSV-1 and H1N1 virus challenges in this paper is that renowned virus hunter Dr. Ian Lipkin and team are heading down a similar experimental path in their ME studies. In Dr. Lipkins talk at the CDC last September he presented...

New optical microscopes have become powerful enough to observe mitochondria in real time in 3D and that is bringing new insights. In the past cells had to be fixed to slides and put in an electron microscope to get a good picture, and that process changes the cells. e.g...

Using model cell lines means that the experiment is controlled in certain ways (1) U2-OS cells prevent virus replication as they didn't want this effect in the HHV6 experiment (2) A549 - virus naive - no other virus in these cells (3) they are just looking at the effect of what is added to the...

The paper did report on the use of a mass spectrometer to look for protein changes on ciHHV6 reactivated U2-OS cells. Unfortunately they did not do that on the other experiments such as with the A549 cells. Hopefully they will extend this work to look at cellular protein changes between cells...

Just to be clear with all the talk about PBMC's. Prusty used U2-OS and A549 model cells that you can buy and grow for the experiments as they have specific properties that he used to control the experiment. From Health Rising article The A549 lung carcinoma cells were virus naive and could be...

That diagram is a bit confusing. It is so easy to miss the "or" which shows they are separate experiments.