Search results for query: migraine

  1. Hutan

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    ...'we created another cohort with 354 ME/CFS individuals with or without hypertension, depression, asthma, IBS, hay fever, hypothyroidism or migraine'? It's not clear how that cohort differs from the full cohort where all the individuals presumably also are 'with or without' the 7 conditions...
  2. A

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Personally my migraine triggers are the exact same as my PEM triggers. And taking a triptan often reduces my ME/CFS symptoms a lot. However, migraines are not known to cause limb pain! All of my symptoms, besides the limb pain, can be explained by several other conditions I am lately finding...
  3. Hutan

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    There was a study that looked at correlations between ME/CFS and all sorts of health conditions in the UK Biobank data. There is a thread on it somewhere here. I remember poking around in the data, but I think I felt in the end that the ME/CFS labelling was probably too noisy to tell us much...
  4. Trish

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    ...fluctuates in severity in some way in parallel with the core ME/CFS symptoms. So for example if someone's PEM includes IBS flare ups or migraine headaches, that might indicate it's part of their ME/CFS, or at least closely linked with it. On the other hand if someone has had asthma since...
  5. obeat

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    OI is a symptom in 40%of migraineurs I had chronic migraine for over 20 years. 2 years ago over a three month period my migraines came to an end and my severe/severe ME symptoms improved to moderate/severe. My hunch is that a third factor is involved in both because although Triptans were very...
  6. C

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    I used to describe PEM as a migraine-like state without the headache. Unfortunately the neurologist just looked at me like I was crazy and sent me away instead of trying to see if common migraine meds would provide any relief for feeling this way. Migraine is a very good comparison because PEM...
  7. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Interesting! Maybe another similarity, from Wikipedia: A paper discussing whether ME/CFS might improve during pregnancy: Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years (Journal of Midwifery & Women's Health, 2008) There's a...
  8. Hutan

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    ...ME/CFS group using these medicines, but e.g. only 0.5% of the people in the IBS group using the medicines, only 0.6% of the people in the migraine group using the medicines and even in the hypertension group, only 9.7% using the medicines, it seems likely that the adjustment had a material...
  9. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    ...on chromosome 17 at position 52183006 is strongly associated with ME/CFS at a log10p of 8.67. You might pull up a summary stats file for migraine and look at that same location to find that it was also strongly associated with migraine, which might suggest that this same variant has the...
  10. DMissa

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Okay, so there's a summary statistic from the GWAS. Got it, thanks! I have basically 0 exposure to this stuff.
  11. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    ...summary stats give us an idea of how much each variant is associated with ME/CFS on a population level. They obtained summary stats for migraine and several other conditions as well, and compared each condition's summary stats to those for ME/CFS. Basically, how well do the variant...
  12. Murph

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    https://pubmed.ncbi.nlm.nih.gov/20713557/ The present study assessed age- and sex-specific patterns of migraine prevalence in a US population of 40,892 men, women, and children who participated in the 2003 National Health Interview Survey. Gaussian mixture models characterised the relationship...
  13. DMissa

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    Right, so what I mean is, specifically, what are the genetic correlations or influences being tested? Is it some sort of singular aggregated value describing genetic variation in the individual? Or is it against specific gene variants? I couldn't tell from reading (thanks for helping)
  14. forestglip

    Preprint Insights into Pathophysiological Pathways in ME/CFS Through Genetic Correlation and Mendelian Randomization, 2026, Wielscher et al

    ...showing how similar the genetic influences are for two traits. If completely different variants were associated with ME/CFS compared to migraine, then the genetic correlation would be 0. If the exact same variants were associated in the same direction with both, the genetic correlation would...
  15. M

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    Yes you would have more diabetes but less than 5%, it generate noise but not a strong signal because the other more than 95% don't have diabetes. Multimorbidity is a feature of me/CFS, you don't see the level of multimorbidity in any of these other conditions. That's why I highlight that while...
  16. forestglip

    Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank, 2024, Huang et al

    I guess I don't see why not. Maybe I'm not understanding something about the methods. There will probably be a portion of migraine sufferers, or asthma sufferers, who have type 2 diabetes or any of dozens of other conditions, just due to some people having more than one condition due to random...
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