Search results for query: migraine

  1. Jonathan Edwards

    Review Migraine and functional neurological disorder (FND)—a review of comorbidity and potential overlap 2025 Stone et al

    I googled 'pathophysiology of migraine'. The AI summary response is interesting in that it is really terrible - complete bullshit that ultimately says 'nobody has any real idea, or if they do the research community as a whole isn't aware of it'. Surprise surprise it mentions mediators as...
  2. Utsikt

    Review Migraine and functional neurological disorder (FND)—a review of comorbidity and potential overlap 2025 Stone et al

    How they explain migraines: This next part is outrageous. They acknowledge that predictive processing and allostasis are theoretical unproven concepts, but claim that they still have use in rehabilitation and treatment. Even more insanity: they say that the understanding of migraines have...
  3. Jonathan Edwards

    Review Migraine and functional neurological disorder (FND)—a review of comorbidity and potential overlap 2025 Stone et al

    Forget the FND but maybe the 2-3x female predominance for migraine can tell us more about ME/CFS. In our Qeios article we suggested that this sort of ratio is largely seen in autoimmune diseases. But migraine seems to show a similar major female predominance. Migraine may be more about blood...
  4. Andy

    Review Migraine and functional neurological disorder (FND)—a review of comorbidity and potential overlap 2025 Stone et al

    ...bowel syndrome, persistent fatigue states and chronic primary pain syndromes such as fibromyalgia.85 A similar overlap for both FND and migraine would support a mechanistic connection." Ref 85 is to...
  5. Andy

    Review Migraine and functional neurological disorder (FND)—a review of comorbidity and potential overlap 2025 Stone et al

    Abstract Migraine and functional neurological disorder (FND) are two of the most common conditions in neurological practice. It is assumed that the two conditions have distinct underlying mechanisms. However, it can be clinically challenging to disentangle their relative contributions to a...
  6. hotblack

    DecodeME in the media

    ...after an awful overnight ‘stay’ because ‘there was nothing wrong with me’ as the senior dr there said in their assessment ‘maybe you had a migraine’. Despite the fact I had to be taken there in an ambulance and couldn’t walk out of the place. ‘Oh you’re still here’ were the words of one...
  7. B

    DecodeME in the media

    ...drama that doesn’t land because people don’t have empathy for us - most don’t hear dark rooms and get what we hope they do. They think of migraine or why are they there and we never expand on why they see some out in public and apparently then talk of this. This is our chance to finally...
  8. E

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    I completely see your point, but at the same time I think one can similarly argue that the genes picked up here aren't that much more different in nature to the genes picked out in the FND study which was my main motivation for asking the question in the first place, where that exact argument...
  9. Simon M

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    ...links to research participation etc).. Also, GWAS findings I'm aware of often tie in with what is already known biologically. E.g. for migraine and RA. And arguable ME/CFS, where findings pointing to immunological and neurological issues are hardly a surprise. Not least the link to infection...
  10. Andy

    Spreading depolarisation (SD): a potential underlying mechanism in functional neurological disorder (FND) 2025 Carlson et al

    ...its pathophysiology, several knowledge gaps exist. Spreading depolarisations (SDs), waves of cortical electrical disturbance best known in migraine aura and implicated in conditions like stroke and traumatic brain injury, have not been investigated in the context of FND. We present a...
  11. T&O

    Muscle fatiguability after exertion

    ...asked (when covering current symptoms with my acupuncturist) is that its a central headache ,and truely feels like the discomfort begins around the center of my brain (in comparison to the front of brain ,typically a gut or upset digestion headache, or over one eye leading to migraine style...
  12. Hoopoe

    ME/CFS and fatigue at the level of neurotransmission

    ...from damage to myelin. In the context of ME/CFS, I'm thinking about neurotransmission in the CNS. That could have all sorts of effects. Migraine affects the brain and makes people feel awful. The feeling of effort and fatigue associated that we often experience might be what poor...
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