Search results for query: migraine

Yep if it turns out to be a neurological CNS illness that is frankly indistinguishable from being neuropsychiatric we are all well and truly fucked, period. This would be devastating

...The former is doing some of the most advanced epilepsy research with brain organoids, which would not be possible here. [Edit: advances in migraine are limited to prophylaxis for spreading depolarization, which is a brief phenomenon that is not the causal mechanism mediating actual migraine...

...research. I don't think a brain solution is necessarily further away than an immunological one. I think the examples of epilepsy and migraine may actually be very relevant. I also think that even if the shift in dynamic state is in the brain that manipulating input from immune signals may...

...without an animal model] and the even more limited conclusions that could be drawn from any of it. The few examples of successes with migraine and epilepsy are mostly due to the triggering phenomena in both cases being substantially different to the sort of “broken loop” mechanism proposed...

...would be so hot it felt like burning if I had a hand on my forehead (to use that image), or placing it on a leg or a forearm. This coincided with migraine attacks, and I've mentioned it on here before how my child migraine triggers closely match my PEM triggers now (but I no longer have...

...response. But then we don't often see responses that aren't at least normally based in an adaptive context. There is a contrast with migraine, epilepsy and narcolepsy/cataplexy, all of which seem to occur mostly out of the blue and not as responses at all. But PEM does appear to be a...

Are you referring to migraine? From what I've read is that migraine had a slight increase in the number of lesions but that there was no evidence of neurological impairment related to these changes.

Depolarisation is signalling (especially if it spreads) and if it is abnormal and associated with symptoms it should not be there!

Could you share any relevant papers about this? I read up on migraine quite often since several people in my life suffer from them, and have not come across any papers showing that migraine occurs when the brain generates a signal that should not be there. Spreading depolarization is the...

Talked about an idea in this thread - Could nerve damage or retrograde microtubule based transport in axons explain the delay associated with PEM? about whether the time delay associated with PEM could be linked to the amount of time it takes from nerve injury/an event at nerve terminals to the...

...How you investigate that beyond more refined genetics I am not sure. I just wonder whether it would be worth looking for links with migraine on the basis that that seems to be another situation where a brain loop generates signals that should not be there. 3. Where 1. focuses on T cell...

...The waxing and waning is the tricky bit. People improve and then relapse - all over it seems. That takes me back to the 2016 Fatigue article and immune and nervous system being the only ones complicated enough to explain this sort of fluctuation. I think it might be brain. Like migraine...

...involvement with ME. I have neuropathic itch on my arms that onset at same time as my ME but worsened in past two years. I had Botox for migraine which unexpectedly mostly suppressed the itch (it’s done down neck to shoulders so affects nerves going to arms), although it returns a little a...

What I meant to say was that as a 5 year old child, I had a better understanding of the cause of a migraine than these research authors

The first migraine I remember was about age 5, I thought my brain was breaking and something was seriously wrong, but I was alone in bed and unable to move to ask for help. At 7 I was sent home from school with one, and was confused with everyone saying “it’s her first migraine” it certainly...

Is anything actually properly known about migraines? Or is there only rubbish?