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My early experiences of ME convinced me that it was neuroimmunological. I didn't have any physical limitations from it. So far I haven't seen any "sound science" to change my bias. That's what I mean about judging hypotheses on whether they "feel right". We factor in the "sound, proven...

So do I. However, I'm still waiting for the "sound science" explaining ME. This forum would be pretty empty if it was limited to known facts about ME. Speculation by non-scientists isn't without value. Discussion, even about far-out ideas could trigger thoughts in the right direction. Even...

I was going to check that vaguely-remembered fact, but ME made me not make the effort. Still, there is long-range interconnection between some brain cells. If it's a neuron affecting multiple areas, that neuron does depend on glia for support, so a glial malfunction could have long-range effects.

The brain has some cells that communicate over long ranges. Imagine ME altering a glial cell that reaches into several different parts of the brain. When that cell activates, it could affect calf muscles and maybe the "need to pee" signal and thymus gland function. In another person, that...

Sure, but there is no sound scientific understanding, data or evidence to base decisions on yet. Intuition may not be reliable, but if the alternative is pure random choice, intuition at least has some chance of being better. The brain might factor in some long-forgotten bit of textbook...

... unless you have a strong negative response to a metabolic product of fibre fermentation. I developed that earlier this year, and had to avoid fermentable fibre. Oral acetate had no effect; probably absorbed/used before reaching the colon. I seem to have a stronger response to pectin...

Another "everybody knows" bit of knowledge shown to be wrong. Is understanding of ME being held up by a similar incorrect "everybody knows"?

Okay, bad wording. My brain weighs the evidence for and against the claims based on whatever is stored in my neurons from past reading, and has a positive or negative judgement. Intuition is a valid method of judging things when there's inadequate data for stronger forms of judgement. If you...

My PEM triggering was different. It seemed to be triggered by abnormal muscle use. If I worked up to a daily 40 km bike ride, that wouldn't trigger PEM. Climbing a few steps up a ladder (uncommon activity) would trigger PEM, because it strained those muscles (and connective tissue?) beyond...

"Although space does not permit a thorough review," -> "We ignored any literature that didn't support our hypothesis."

The AI findings don't "feel right" for ME's cause. Another study I heard about today was a re-analysis of existing studies which revealed that peroxysomes were abnormal in ME. To me that seems a much better fit for explaining ME.

I'm a coffeepot short and stout. :)

I think PEM as a mandatory criteria is important for study subject selection. It might even be wise to limit selection for a given study to certain criteria for PEM, such as "reliable 24 hr delay". Adding in non-standard subjects could blur the data enough to hide a correlation. Using that...

That seems like useful, productive science. When some flaky health magazine article say "Lactic acid is bad! Drink bicarb!", someone can point to actual scientific knowledge about lactic acid in the body. It's also useful for such things as understanding ME. Theoretically, does lactic acid...

Humans are gullible, and there will always be those who jump for the next "magic" treatment. You can provide rational arguments and point out the lack of evidence, but if they want to believe in magic treatments--or ghosts or astrology--they are going to, and other people will exploit that...

Isn't that a circular argument? PEM is a required symptom because all people who fit the criteria including PEM have PEM. There might be a considerable number of people who have the same core dysfunction of ME but get a negative diagnosis for ME because their ME doesn't result in PEM. If PEM...

Yes, that changes it, although the post does say "patients", so it does fit people who did find something and post the "You gotta try this!" message (without waiting to see if it continues working or has side effects). Well, you could get a paper cut. More seriously, you could get kidnapped by...

Yes, especially since ME has the habit of working for one or two doses, then stopping working and never working again. Luckily, none of my effective treatments had any significant side effects.

I challenge the "consistently" part. I did experience what may have been OI, but only for a few months of my 20+ years of ME. If I did exertion, such as lifting something heavy or running even a few steps, when I stopped, I'd start to feel faint, maybe get tunnel vision. However, that was...

I've managed to stumble across several treatments that worked really well for me, so I did post about them. Sadly, aside from LDN, the others didn't work as well for anyone else. However, unless other people tried it, there was no way to know that it wouldn't work for them. Luckily, they...