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Discussion on Vortioxetine for ME/CFS here

Abstract Hitherto no therapeutic has received regulatory approval for the treatment of post-COVID-19 condition (PCC). Cognitive deficits, mood symptoms and significant reduction in health-related quality of life (HRQoL) are highly replicated and debilitating aspects of PCC. We sought to...

Canadian Covid Society launches to address long-term effects, prevent further illness A new non-profit group called the Canadian Covid Society launched today...

Abstract Mitochondrial respiration extends beyond ATP generation, with the organelle participating in many cellular and physiological processes. Parallel changes in components of the mitochondrial electron transfer system with respiration render it an appropriate hub for coordinating cellular...

Introduction: Pulmonary endotheliopathy and microvascular immunothrombosis play a key role in acute COVID-19. Moreover, persistent endotheliopathy and heightened coagulability frequently occur in individuals recovering from COVID-19, suggesting the intriguing possibility of their role in the...

Are they checking your ferritin? My sister has low iron levels from Hashimoto. Did you get your thyroid levels tested?

Abstract Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with in vivo biosensor imaging to...

I have a 3 page report re RBC fatty acids, my omega 3 levels were at 3%. All the the others were within normal range. Taking plant based oils didn't work for me based on my results. I take Webber triple Omega 3 fish oils b/c it's IVO My brain function had noticeably improved after...

Dr. Keagen's responses on X I find keeping up with the emerging research on long-covid a bit daunting, and I teach it. The core to caring for someone with long-covid is (1) believe them, (2) take a great history, likely focused on chest pain, fatigue, brain fog, mood disorder, difficulty...

Introduction: Oxygen toxicity has been defined as acute central nervous system (CNS), acute pulmonary, and chronic pulmonary oxygen toxicity. This study identifies acute and chronic CNS oxygen toxicity under 2.0 atmospheres absolute (ATA) pressure of oxygen. Methods: The authors’ medical records...

I tried a gluten free diet for almost a year even though I tested negative for gluten sensitivities, I cooked with cast iron pots, ate plenty of liver and roasts with vitamin C, took digestive enzymes that might have helped a little, eradicated h pylori, ate fermented foods . . . I...

Hundreds line up outside Kingston clinic in desperate bid for a family doctor. https://www.cbc.ca/news/canada/ottawa/hundreds-line-up-outside-kingston-clinic-in-desperate-bid-for-family-doctor-1.7130133 Scary times in Canada.

Abstract Type I Interferons (IFN-I) are central to host protection against viral infections. While any cell can produce IFN-I, Plasmacytoid Dendritic Cells (pDCs) make greater quantities and more varieties of these cytokines than any other cell type. However, following an initial burst of IFN-I...

My 25 hydroxy test from 2006 was at 26 from taking 1000iu's daily. I checked over my results from 2007 from taking 3000iu's vitamin D for 6 months: Vitamin D (25HYDRO) - 144 (ref 25-200 NMOL/L) Vitamin D (1-25 DIHY) - 153 (ref 40-150 PMOL/L) Came with a 'warning'. These tests were taken after...

Merged threads Low ferritin levels for pwME has been a mystery. My levels were normal when I was tested by an Internist during the first year of illness, but rapidly started decreasing for no apparent reason for many years after. I took iron supplements regularly. No one could figure...

Interesting that an Emergency Medicine doctor is posting on Reddit for info on how to deal a 'difficult' LC patient. Receiving decent suggestions though and not 'it's all in their minds", unlike pwM.E.

Another thing is that you won't absorb vitamin D if your magnesium levels are low. So, how does magnesium affect vitamin D biology in the body? It is a cofactor in the synthesis of vitamin D from both exposure to sunlight and dietary sources. “Magnesium deficiency shuts down the vitamin D...

My vitamin D levels went over the ref range when I started taking 3000iu daily years ago. I take 2500's daily during the fall, winter and spring months but can't get tested anymore. I don't take any during the summer as I'm able to sit out and get sunshine.

Early on, I squeezed my way into the long COVID clinic at UHN, led by Dr. Angela Cheung. Just having some validation and a diagnosis was helpful. I learned that I had a combination of long COVID phenotypes, or groupings. The first is the brutal cocktail of severe fatigue, brain fog and...

There is also a problem if patients aren't getting their vitamin D levels tested before they start supplementing.