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It doesn’t treat bad breath. Major red flag for me.

Yup but 3-4% increase in donations is good actually.

Over $100,000!

What do you mean by reversed? Sleep all day, awake at night?

I’m sleeping more during the day, and probably less during the night—I assume this is associated with increasing severity? Do severe/very severe bed bound people spend most of the day sleeping or are they mostly awake and resting while awake? On this live Physics Girl webcast there is a big...

Warren Buffet was great at making money—not so good at giving it away. Between the lines: Buffett's three children don't make for natural charitable bedfellows. Susie, 71, runs the Sherwood Foundation, which is focused on Nebraska. Peter, 66, runs the NoVo Foundation, which "supports...

https://www.science.org/doi/10.1126/science.add8394 Structured Abstract INTRODUCTION Enhancers are distal cis-regulatory elements that increase the expression of target genes. Active enhancers produce bidirectional enhancer RNAs (eRNAs). Transcription of eRNAs can be used to measure enhancer...

2029 is too long—I agree. I also wish that Lilly was fully funding this—but I guess they are not.

Peluso has it all figured out! "Long COVID is not a mystery," says Michael Peluso MD, an infectious disease researcher in the UCSF School of Medicine who co-led the study. "Our findings provide clear evidence of virus persistence and sustained immune activation after COVID-19. We must use...

Here is Wes Ely’s email reply to my query about whether he had any pilot scale data on Bari for LC patients—he didn’t really answer the question, but at least he responded. “Thank you so much for your kind informative email. One of my fundamental rules before embarking on any research project...

Speaking of Parkinson’s Biden— Today I signed the National Plan to End Parkinson’s Act – a law that will help prevent, treat, and cure Parkinson’s disease and similar disorders. This law is about dignity. It gives people hope that we can end this cruel disease and that we can still do big things.

Yes, but if no shit is thrown at the wall, there is zero chance that anything will stick. Yes, I do advocate for throwing shit at the wall, especially when trial costs are borne by pharma companies.

Seems like every nut is being cracked except for ME/CFS.

Thread from Precisionlife

Any other news from this conference? Janet Dafoe The last 2 days at Invest in ME have been really goood. New young investigators and fab “old” intrepid ones. From many countries. New this year were a LOT of references to interventions, treatments, clinical trials. Lots of research progress...

I missed that sentence.. but how many people have tried amino acids and butyrate to no effect?

I don’t see any suggestions for treatments here. I believe that Unutmaz said that they were going to list suggested treatments. If he/they have some potential treatments in mind based on this research, then they should put that in the paper. Maybe we need to wait another six years (according to...

Another one bites the dust….

Umm I’ll save you the time…..it doesn’t work.

Here are the various multitudes of drug trials for lupus, which is classified as a rare disease. Maybe in twenty plus years we might have a pipeline like this for ME/CFS. This is a great figure/visualization. Data from this paper apparently...