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As per comments above, we don't know if this finding will be replicated in a larger GWAS study - DecodeME or whatever. However, on the face of it, this could potentially explain why no biomarker has been identified in ME/CFS i.e.: presumably the effect of this gene (TPPP) is to expressing a...

Interesting i.e. "I don't suppose, when the team from Harvard TH Chan School of Public Health did their big longitudinal study (10m blood samples from US military personnel over 20 years), they looked at incidence of ME/CFS as well?" If you search on this thread then I think you'll find a...

@CRG & @Shadrach Loom only scanned this but possibly a Parliamentary Question which welcomes this initiative and ask whether it will end NIHR funding for low/very low quality research into ME/CFS i.e. unblinded studies using subjective outcome criteria (questionnaires) which provide no useful...

I'd be inclined to act now. Sajid Javid Secretary of State for Health and Social Care* has been making the right noises** "We need to do more on ME/Chronic Fatigue Syndrome. There’s been a real lack of research over many years". Sajid also met with Professor Chris Ponting [Genetic Study "GWAS"...

@CRG and I have been attempting to raise the issue of funding for low/very low quality research*. I've also written to the APPGs i.e. asking them to challenge Government funding for low/very low quality research - typically unblinded studies with subjective outcome criteria (questionnaires) -...

Found myself chuckling as I skim read the abstract - some good then!

I have a "ninja foodi max ag551uk" - in fact I have 2! I bought one and the internal temperature probe stopped working - it's a metal probe you stick in your food and set the temperature ---- 74 degrees C for chicken or whatever. Anyway I wrote to them and they said here's a refund code bring it...

I haven't looked at this, and my knowledge is very limited. I'm wondering about the quality of the tests; I've seen comments here that some studies use linear peptide arrays. So the results are unreliable to begin with. There's a thread here* re a better technique and I think Solve funded one...

Some weird stuff re amino acids* when diet is low the body increases consumption of them - suppose that links to ME/CFS as starvation but can't see how relates to proline reduction/sensitivity *https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093597

Amino acids have featured in ME/CFS e.g. Chris Armstrong did some MRI work and found some depleted (he suggested these were consumed for energy i.e. even though glucose was high) and some elevated (suggesting they weren't used). Fluge and Mella followed that up around 2016 by suggesting that PDH...

I would have thought doing a review of the evidence base for exercise in ME/CFS was up there with the easiest review ever. If Carlsberg did ---- Most/all of the studies are unblinded and use subjective outcome criteria, so there is no evidence to review. This comes to mind "If nobody is trying...

Haven't looked at the above. One from my small repertoire of stock answers; I assume that there would be clues in Chris Pontings GWAS study i.e. if redox was an issue. Also, from memory there are some standard tests for redox [Glutathione Peroxidase - GPX?]. So I'd expect something to turn up...

I think the key thing here is that the lead on DecodME actually cares. Chris Ponting has spoken about the driver - he knows Simon and was keen to try to help. Apologies but those running Cochrane don't care. If they did then there are ample opportunities identified on this site about how to...

Fair enough i.e. "that is beyond their [Cochrane's] remit, their (volunteer) authors would not want to or have time do it" but why are NICE funding them?

Please keep asking and thank you for publishing it on social media --- that way it's more likely to come to public attention/decision makers attention. Ultimately that may be the way to force Ministers (and thereby NICE) to disown Cochrane ---- Cochrane can't objectively assess the quality of...

Loads of dosh for those benefitting from ineffective treatments --- of course there are incentives to leave them in place. With respect, I think the real issue is that now that we have an objective appraisal [see reference to Peter Barry above] i.e. that these interventions aren't effective...

My initial reaction was that the responses to the consultation would be pretty damming (polite phrase) - even allowing for some delusion, and/or defences based on self interest, i.e. those responding on behalf of Cochrane, the whole idea of a consultation seems like a car crash with Cochrane the...

I'm not sure - I have no direct experience. However, it may be: a way to generate useful views from constructive elements/participants re translating the guideline into practice; a useful way to moderate the behaviours of the destructors (weirdly the medical professional bodies) - let them...

Yea there seem to be a few of those high profile folks around --- they may be disproportionately represented --- by their own loudness --- many much better Doctors probably are frustrated that they cannot help ---- which is where lobbying - for research, centres of excellence (specialist...

Sounds reasonable maybe the challenge should be to NICE i.e. now it's signed up to a co-operative agreement! Possibly a Parliamentary Question and/or an email to the APPGs (ME/CFS & Covid).