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Remember wall street 101: Buy on rumor, sell on fact. 12% is a small move for a stock like this. Also, realise that their shares were worth at their peak, $32.25 last September..

The article is basically a narrative review of the various names and clinical definitions for CFS over the years. The article doesn't really delve into etiology nor treatment. Google Translate conclusion:

Surprising how different the results were across the other patients vs the one they cherry picked for this "case-study".

I don't think Vermeulen can publish the data on that slide, because it is just routine clinical data and was not collected as part of a study with ethics approval. There was another Vermeulen study that may be relevant to this discussion too...

Yes, Australia actually spends more than many countries despite it's smaller size... UK: https://mrc.ukri.org/about/what-we-do/spending-accountability/facts/ (about $1 billion USD) Australia: https://aamri.org.au/news-events/2019-20-federal-budget-whats-in-it-for-medical-research/ ($730...

Vermeulen 2010 found significant reductions in VO2Peak, but this has not been found in later studies and the image you quoted clearly shows a plot of VO2Max on day 1 vs VO2Max on day 2. As I have explained previously, we cannot assume VO2Peak = VO2Max and I believe this is the reason for the...

Indeed.. But since this article was not approached in a systematic and empirical manner, it could also be considered an exercise in confirmation bias. Reducing everything down to mind-body dualism when that might not have been the intended meaning in the various examples covered. There is...

Quite right, these studies are hard to control properly and many of them have shown both patients and controls having well above average intelligence - or abnormally distributed intelligence, suggesting substantial biases.

I wonder if/when the comments will show up

Click on "article info" for a date https://mh.bmj.com/content/early/2019/06/07/medhum-2018-011588.info

https://mh.bmj.com/content/early/2019/06/07/medhum-2018-011588 Perhaps there is more to come (something from Sharpe?)

Yes, apparently all we have to do is stop paying attention to symptoms and then the symptoms will magically disappear!

I am speculating and would bet a reasonable amount of money on it.

I find this curious as I know some ultramarathoners who can run 500+km in a week... They'd be burning on average about 4000-5000 Cal(kcal) per day on top of their BMR. The implication is this cannot be maintained for 20 weeks...

Here is a youtube playlist of another person before and after the surgery. They have EDS and had the following key symptoms - neck pain, headache, brain fog, severe fatigue, mild hand tremor and ataxia.

A key point still is that Jeff and Jen ended up developing symptoms that are quite atypical of ME or CFS. I don't see why it is controversial to believe that their symptoms were due to CCI and that surgery was the cause of the remission. Perhaps they had rare atypical presentations of CCI -...

It makes me wonder, have there been any animal models of disease that have actually led to effective treatments in humans? I'm guessing the list is quite short?

He's saying that ME does have clear signs. It is only invisible if you don't care to look.

I was specifically referring to the performance at the ventilatory threshold, not VO2Peak. The conclusions that the authors are making about VO2Peak are assuming that patients and controls actually achieved their VO2Max, something which I am sceptical about. Why would we assume that patients...

I think it is important not to speculate as to the reasons why until we are told more details...