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    Example of Perception of Symptoms being misleading

    I think I understand what Trish is saying better than what you're saying, even though I feel like it's roughly the same message. Nobody "feels like they are producing only 50% of the normal amount of ATP", because nobody feels any form of ATP generation. What one might feel is having little...
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    Preprint Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry, 2024, Pretorius

    I think they should be more than just aware of this. If I recall the results by Dalton et al, they had shown that this kind of storage completely nullifies any results and makes them useless. Haven't gone through the study yet, but the deciding factor would possibly whether controls had been...
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    Short- and long-term neuropsychiatric outcomes in long COVID in South Korea and Japan, 2024, Lee et al

    Short- and long-term neuropsychiatric outcomes in long COVID in South Korea and Japan Abstract We investigated whether SARS-CoV-2 infection is associated with short- and long-term neuropsychiatric sequelae. We used population-based cohorts from the Korean nationwide cohort (discovery...
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    Establishing a "Ground Truth" Resource for ME/CFS

    Indepently of the use of AI this seems to be a good idea to keep track of replicated and non-replicated findings over the years and decades. Would be awesome if one could get one of the organisations involved.
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    Evidence Circulating Microclots and Activated Platelets Contribute to Hyperinflammation Within Pediatric Post Acute Sequala of COVID, 2024, Okuducu+

    I have no idea either, I think one will have to wait for the references to see what the authors might be meaning. There's many different terms, sometimes used interchangeably and sometimes not. Sometimes the time frames of various terminologies differ (for instance 4 weeks vs 3 months) and...
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    Animal research for ME

    I'm not so sure. To me it shows the discussion is more nuanced and that one should be informed about these nuances before one makes conclusions or even accusations. Here is one of plenty examples of a project that was partially funded by ME Research UK in which mice were involved...
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    Evidence Circulating Microclots and Activated Platelets Contribute to Hyperinflammation Within Pediatric Post Acute Sequala of COVID, 2024, Okuducu+

    Evidence Circulating Microclots and Activated Platelets Contribute to Hyperinflammation Within Pediatric Post Acute Sequala of COVID https://www.atsjournals.org/doi/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A2247
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    Animal research for ME

    I'm not able to understand how the repeated example of lab reagents generated in animals is not self-explanatory of the situation. That overview has no relevance to what I said. The problem is not the lack of the existence of lab mice, no one has ever suggested that. Such an experiment would...
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    Animal research for ME

    Where are you getting these ideas from? Was the example of lab reagents generated in animals several pages ago not precisely such an example for this being a more nuanced discussion? Well the studies you have cited only ever used a handful of mice. Perhaps talking to those researchers would be...
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    Animal research for ME

    But clearly ME Research UK and Action for ME does fund research that involves the use of animals as @Jonathan Edwards has already explained, they are not "vegan" in that sense. 2 out of the 4 charities simply oppose to animal model studies as far as I can see. I think there might also be an...
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    Animal research for ME

    Indeed I was selectively quoting to emphasize the fact that if you infect a load of whatevers that doesn't mean that you end-up studying LC, i.e. "that is the part that is still possible". I did so because understanding that part is the crucial part. The fact that no one in human challenge...
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    Animal research for ME

    That is the part that is still possible. There are and have been several human challenge studies with Covid. The researchers conducting those studies believe that not a single participant developed LC as part of those studies and that is the important part. The piece that leads to LC is not a...
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    A causal link between autoantibodies and neurological symptoms in long COVID, 2024, Santos Guedes de Sa, Iwasaki et al

    It seems "causal" is used somewhat vaguely here. The data on the cohort seems to be lacking. I can't see any information on illness duration, last known infection, BMI, comorbidities, etc. Furthermore whilst they started of with a large cohort in later experiments they are using various...
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    A causal link between autoantibodies and neurological symptoms in long COVID, 2024, Santos Guedes de Sa, Iwasaki et al

    A causal link between autoantibodies and neurological symptoms in long COVID Abstract Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated autoantibodies have been found in some individuals with long...
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    Opinion Challenging the current hypothesis that thrombosis is responsible for the post-COVID-19 condition, 2024, Carson, Davey Smith, Garner et al

    Maybe David Jameson has been active again (who btw seems to also actively be reading on this site, so hi to you David :))?
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    "The idea of rehabilitation needs to be completely rethought for this disease" A qualitative analysis of patients' experiences, 2023, Hammer et al

    „Der Reha-Gedanke muss bei dieser Erkrankung völlig neu gedacht werden“ – Qualitative Ergebnisse einer Online-Befragung zu Erfahrungen Betroffener mit stationärer Rehabilitation bei Long/Post-COVID Abstract Background In Germany, an estimated number of 70,000 people diagnosed with long COVID...
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    Systems Modeling Reveals Shared Metabolic Dysregulation and Novel Therapeutic Treatments in ME/CFS and Long COVID, 2024, Gong-Hua et al

    I cannot comment on the merits of their method, but I think it's excellent that people on this forum and elsewhere are analysing and re-analysing some of the data from the intramural study. I do think it contains some valuable information (for example on diagnostic accuracy, POTS/POT/OI, etc)...
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    Systems Modeling Reveals Shared Metabolic Dysregulation and Novel Therapeutic Treatments in ME/CFS and Long COVID, 2024, Gong-Hua et al

    First off it’s good to see research on LC and ME/CFS coming out of China. It seems like they used a novel metabolic modeling method called GPMM (Genome-wide precision metabolic modeling), which is something the authors for example used, or possibly introduced, in this paper...
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