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[University of Miami - 2009] Clin Sci (Lond). 2009 Oct 19;118(2):125-35. doi: 10.1042/CS20090055. Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function. Hurwitz BE1, Coryell VT, Parker M, Martin P, Laperriere A, Klimas NG...

I believe you can measure the blood volume by injecting a measured dose of a radioactive marker into the blood stream. After the marker has thoroughly mixed with the blood supply, you can then remove some blood and the amount of marker and its ratio to the amount of blood taken will tell you...

Ironically, the treatment involves cellular metabolism, pyruvate and the production of more lactate.

His range of interests may have expanded over the years... ______________________________ Br J Psychiatry. 2002 Sep;181:248-52. Predictors of response to treatment for chronic fatigue syndrome. Bentall RP, Powell P, Nye FJ, Edwards RH . . . RESULTS: Poor outcome was predicted by membership of...

This is kind of confusing to me because Wikipedia and other sources say there is about a 40% treatment-related mortality rate in HSCT (aka Bone Marrow Transplant), yet that's not mentioned in these articles. https://en.wikipedia.org/wiki/Hematopoietic_stem_cell_transplantation#Complications...

That is really odd. Is it possible that there is some information that is being conveyed in the initial phone call that is scaring people off? Or could they have been given a call back number that puts them on hold forever? For no one to call back sounds like a real systemic problem that may...

I don't object to this requirement, but it does reduce the pool of potential candidates quite a bit. Not only is it estimated that 91% of patients are undiagnosed, but, in 29 percent of the cases that are diagnosed, that diagnosis took more than five years. So something like only 6.4% of all...

I think, if someone is going to join under the name and logo of a real organization, there should at least be some requirement that they be able to prove that they do indeed represent that organization. Do we want some random actor to be able to join and call himself "The National Institute of...

I appreciate that. I was just trying to point out that Komaroff wasn't exactly giving the therapy recommendations in the review articles a ringing endorsement.

I remember being amazed at how many of the drug descriptions in the PDR (Physician's Desk Reference) contain the phrase "The exact mechanism of action is unknown." Trials had proved that the drugs were effective, but why they were effective was often unclear.

It may be that research on NLP is difficult to track down because most of it was done in the 1970's and 80's, prior to the internet. This 1987 paper looked at 44 studies on NLP and found only 6 which were supportive. Of the six, four of those papers were graduate theses...

This 2017 study from Columbia's Center for Infection and Immunity showed that differing levels of various gut bacteria (called "abnormal levels" in the press release) distinguished ME/CFS patients from healthy controls and also distinguished ME/CFS patients with IBS symptoms from those without...

I don't know how generally accepted this is, but the paper appears to argue that ME emerged into the UK's modern media consciousness in June, 1986. I mention this because you could argue that ME entered the US' modern media consciousness just five days later on 6 June, 1986, when the Los...

A couple of recent studies have shown similar reductions in the micorbiome's diversity in ME/CFS as is seen in Chron's disease and chronic ulcerative colitis (the two major types of "inflammatory bowel disease," or IBD). I believe whether that reduction in diversity is a cause or a consequence...

Could be a lateral move, like, say... just a jump to the left.

I tend to get sinusitis twice a year, once in late spring and once in late summer/early fall. It's pretty clearly an allergy to something. Sometimes my ears get stuffed up at the same time and sometimes I get tinnitus. It usually only lasts a week or so. Also, anytime a doctor looks in my...

I view this somewhat differently. Dr. Komaroff was writing an editorial called "Is ME/CFS Real?" in an issue of The Annals of Internal Medicine in which there were two separate review articles on ME/CFS: one on diagnosis and the other on treatment. So, he mentions the findings of the treatment...

Are calls like this recorded and archived by the NIH? I seem to recall hearing one that way, but I may be mistaken. ETA: I answered my own question. It looks like a transcript and recording will eventually be posted at the link below. I'm not sure how long it takes, though it looks like it...

It turns out that a fairly large percentage of the population harbors the H. pylori bacteria, but a much smaller percentage actually develops stomach ulcers. Thus it's been argued that some factor in addition to H. pylori must be present for stomach ulcers to be triggered. I know I've seen...

Great, comprehensive article on the disease. One of the very best I've read.