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No mention of bias and no methodological assessment of the certainty of the evidence. Lots of bias towards BPS explanations. Only one study with objective sleep tracking. I don’t think this review is worth much..

I just want to clarify my current stance on this: I agree with them that ‘burnout’ is an unnecessary diagnosis. It’s broad, vague and just another way to dismiss patients. But I do not, in any way, agree with their reasoning about e.g. unhelpful beliefs and the proposed treatments. They are...

According to MEpedia, this book has a whole chapter on ME/CFS:

25 = REGAIN, unblinded and subjetive outcomes 46 = study on elderly hospitalised patients. ‘Blinding’ was not telling the patients if they were in the low (40-50 % of max HR) or moderate (50-70 % of max HR) intensity group, or the control group that did nothing in particular. In my opinion...

The quality of RCTs was assessed using Cochrane Collaboration’s tool (RoB-2 tool)29 for risk of bias. This tool includes five domains: randomization process, deviations from intended interventions, missing outcome data, measurement of outcomes, and selection of reported results. Each domain was...

It’s so much worse. I believe they might have been recruited from her phd thesis, which had major flaws. I’ve posted about it on the thread about the thesis, this is my AI-aided summary:

There were some major issues with this study. I have asked ChatGPT to remove the line breaks that came as a result of formatting issues when copying the text, but not alter the text in any other way. So I believe the text is preserved. AI-aided summary: The study initially received ethical...

14 participants in total: «Eleven participants were recruited through a previous study during which they left their contact details for follow-up. Three further participants were recruited via the researcher’s social network to broaden the participant.» A slightly leading question: «The...

Using pseudonyms.

Ogden is one of the professors that resigned in protest of the 2017 special issue that demolished the PACE trial (source: MEA based on a Times article avout emails the got access to): James Coyne, a co-editor on the journal and emeritus professor at the University of Pennsylvania (…)...

Petker’s thesis: https://www.s4me.info/threads/a-thesis-of-clinical-research-and-practice-psychology-and-long-covid-2023-petker.35537/

How to more effectively gaslight your patients. Do they even acknowledge the possibility that they might be the ones that are wrong?

I know they are trying to lump ME/CFS together with anything else with fatigue. We should vehemently oppose the attempted removal of ME/CFS as a distinct concept. But I don’t see why we should be opposed to the removal of burnout because burnout doesn’t make any sense in the first place...

Are those p-values low enough for whole-genome sequencing?

It’s certainly a problem if they try to label ME/CFS and LC as generic fatigue diagnoses, but I don’t see how that’s connected to burnout because burnout is already characterised as a psychological fatigue/stress diagnosis. The BPS-lobby in Norway tries to make everything about stress, like...

I wish the researchers would have left out ‘psycho’.

Would this indicate that the non-imaging tools are not sensitive enough to detect e.g. brainfog unless it’s very, very severe?

Based on a brief skim of the discussion and conclusion, it seems like they are making the case that NICE is firmly in the pocket of big pharma.

So they are adamant that the underlying data has not been affected? A duplicate in the plot could also indicate that the data had an error - how do we know if other analyses have been affected? Surely they would have to rerun their calculations now - and I’m slightly concerned that they don’t...

Welcome, @SineadÓMaolagáin ! I hope you enjoy your stay here - you’re more than welcome to stick around as well :) I believe that these quotes by Jonathan sums things up quite nicely. The issue here is that the participants don’t get enough info about the intervention to actually be ‘informed’...