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Not a review but an overview from last year: https://www.s4me.info/threads/advancing-research-and-treatment-an-overview-of-clinical-trials-in-me-cfs-and-future-perspective-2024-seton-et-al.36803/

I’ve heard lots about Gupta - it was popular among a select few of the early LC community I was a part of. Predatory b*stards.

I take it back - they did a complete u-turn in the next section. They a located in London. Would this qualify as false advertising like what LP used to do? ————— How Acupuncture Can Help CFS According to Traditional Chinese Medicine (TCM), CFS is an imbalance of Qi (vital energy) and blood...

I’ve read worse descriptions! The cynical part of me wonders if they’ve made an effort to ‘please’ potential customers in order to draw them in..

There are probably many different ways to calculate ‘fastest growing’.

I wonder if the intensity or nature of the exertion might impact the delay. Exercise with a CPET is pretty extreme, and might on average produce a quicker response in terms of PEM compared to less intense exertion. Maybe there is some kind of dose response relationship here.

Study, but only abstract (line-breaks added) https://pubmed.ncbi.nlm.nih.gov/40080546/ Mutations in the ubiquitin kinase PINK1 cause early onset Parkinson's Disease, but how PINK1 is stabilized at depolarized mitochondrial translocase complexes has remained poorly understood. We determined a...

So you got worse again 3 months after the infection? I’ve spoke to a few of people that reported the same. Some eventually recovered, others did not.

My pure speculation is that the differences were derived from biomarkers that were correlated with symptoms presentation, and not just based on symptom presentation like we would have to do for PEM. For me instant was like delayed PEM. I get less of it now because I rarely push too far beyond...

Figure 2 Post-exertional malaise scaling example based on a qualitative interview. CPET, cardiopulmonary exercise test. Figure 3 Overlay of post-exertional malaise, physical fatigue and composite visual analogue scales for healthy volunteers. CPET, cardiopulmonary exercise test; PEM...

Description Presenter Steven J. Smith, MD, will speak for a short time with a few slides and then there will a long Q&A/discussion session. Dr. Smith is now retired and publishing research, but in his long career as an interventional radiologist, he noticed that many of his Pelvic Congestion...

I don’t think that’s feasible without a biomarker that we have casually linked to the variability in symptoms.

The thing is that you say that it’s always delayed. Someone else will say that it can be instant. And another person will say that it can be accumulated. All based on their personal experiences and beliefs about how their body works. And because nobody can say that the others are wrong - and...

It’s certainly not redundant! It’s very valuable to get to check the logic - and I have no guarantee of being right just because it makes sense to me. If someone else asks ‘what about this’, we can both say that it has already been addressed. That process is what gives the end results its value.

I’ll add some brief comments to explain my wording and current opinion (which might be wrong or inaccurate). Bolding is mine. I believe ‘report’ is essential to include exactly because we don’t have definitive studies. We can’t risk giving off the impression that the descriptions of PEM are...

This is why it’s so difficult to learn to judge your threshold, because the symptoms and warning signs can change.

Yeah, I think this is what PEM is. And then we could possibly give reports of how different people experience it. But very briefly, like ‘often delayed’, ‘from stimuli’, etc

It’s the approach of pretending that reality goes away or changes if we ignore it.

Those people are at a much higher level of functioning, and it might be that PEM behaves differently at that point. We’ve seen some studies that find differences between mild/moderate and severe (or worse). It might be that whatever PEM is, it behaves differently in bodies with an inherently...

@Evergreen thank you for putting so much relevant info together like that. I agree with this interpretation.