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Editor’s summary Patients with multiple sclerosis (MS) harbor high frequencies of pro-inflammatory B cells, which promote inflammation; yet, it is unclear how cytokine production in B cells is regulated. Li et al. studied cytokine regulation in pro-inflammatory (GM-CSF+) and anti-inflammatory...

I've sent a message asking if they could include post-infectious ME/CFS in their dialogue. I don't understand why Dr. Dr. Satish Raj, MD never mentions ME when he has seen pwME in his clinic. I follow him on X and the silence is odd.

CreeAnn Phillips to lead recruitment for Long-COVID study CreeAnn Phillips, who recently completed her third year in UCalgary’s Bachelor of Health Sciences Program with a major in biomedical sciences, is the 2024 recipient of the Libin Summer Studentship. Thanks to this student award, Phillips...

The term long COVID, also known as post-COVID-19 condition, was coined in spring, 2020, by individuals with ongoing symptoms following COVID-19 in response to unsatisfactory recognition of this emerging syndrome by health-care practitioners. In September to November, 2020, clinical codes for...

How to get a referral without a Family Doctor Your doctor may not believe a second opinion is necessary. That may be because they performed a thorough examination and are confident with their diagnosis, They may not have understood the extent of the problem, perhaps due to a lack of time...

New research, led by University of Cambridge investigators, shows they have developed a new vaccine technology that provides a broad range of protection against coronaviruses, even those that don’t yet exist. This approach to vaccine development is called “proactive vaccinology,” which seeks to...

I posted the above paper here

What I've learnt over the years is to describe the symptoms that you're experiencing, don't even mention POTS or OI, they have no clue what that means and their eyes will glaze over. When I told my GP that I felt pressure in my chest when upright for too long, racing heart at times et...

Merged thread Hundreds of patients died after catching COVID in Victorian hospitals, new data shows Almost one in 10 patients who caught COVID in hospital died ABC News requested interviews with infection prevention and control experts at Western Health, Barwon Health and Alfred Health — all...

#MECFS2023 Next Vishnu Shankar, immunologist in Mark Davis’ lab at Stanford is talking about oxidative stress and suppression of mitochondrial ATP levels in MECFS and Long Covid patients, and reactive oxygen species. He was inspired to work on ME by reading The Puzzle Solver book. September 8...

Canadian Cardiovascular Society Position Statement on POTS syndrome and Related Disorders of Chronic Orthostatic Intolerance This novel classification is on the basis of expert opinion of the Writing Committee on the basis of limitations with the current nomenclature. Suggested diagnostic terms...

Abstract Objectives We aimed to describe the trajectories of cognitive and physical symptoms before, during, and after a positive- or negative SARS-CoV-2 test and in untested controls. Design A prospective cohort study. Setting Norway, 27 March 2020 to 6 July 2022 Participants A total of 146...

Abstract Importance Approximately 55 million people in the US and approximately 1.1 billion people worldwide are postmenopausal women. To inform clinical practice about the health effects of menopausal hormone therapy, calcium plus vitamin D supplementation, and a low-fat dietary pattern, the...

Neuroinflammation was identified across a wide range of brain regions and connected to measures of blood vessel dysfunction https://polybio.org/longcovid-brain-inflammation-associated-with-vascular-problems-harvard-team-finds/

For free speech to be most valuable, it must reach open minds. Open-mindedness suggests an ability to see a perspective outside of one's own. “It's being willing at the very least to have your own viewpoint challenged. Also, to test your thinking a bit,” said Political Science Prof.

Abstract Background Reported orthostatic hypotension (OH) prevalence in Parkinson's disease (PD) varies widely, with few studies evaluating specifically neurogenic-OH (nOH). The ratio of orthostatic heart rate (HR) to systolic blood pressure (SBP) change (Δ) is a valid screening method to...

It would be interesting to hear the discussions on how Prusty will show how ME/CFS differs from long COVID and Wust's presentation on PEM.

How thrilling to see this online after 8 years in the works!!! We showed that #Lyme bacteria mimic our own“don’t eat me” signal with their P66 protein to hide in plain sight!!! This tricks our SIRPa protein to trigger the breaks on immune clearance!

SUMMARY Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are detected by positron emission tomography in people living with MS prior to the formation of structural lesions determined through magnetic resonance imaging. In histological specimens, clusters...

Abstract Innate immunity, the first line of defense against pathogens, relies on efficient elimination of invading agents by phagocytes. In the co-evolution of host and pathogen, pathogens developed mechanisms to dampen and evade phagocytic clearance. Here, we report that bacterial pathogens...