Abstract
Background
We introduce a novel measure for assessing TikTok overuse, called the TikTok Use Disorder-Questionnaire (TTUD-Q). As part of ongoing investigations into the suitability of the World Health Organization’s (WHO) framework for diagnosing Gaming Disorder in the context of social...
Written a few hrs ago:
"Never in my wildest dreams did I think I'd be told I didn't have M.E - this was my community for 14 years and I'd only experienced kindness from them. It is disgraceful to invalidate others experiences".
The Pandemic That Never Left- Heart FAILURE. Although the mortality related to COVID-19 has eased significantly from 2021 highs, COVID-19-related mortality was LOWER than Heart Failure-related mortality both at its peak and throughout the pandemic.
If they can get to the root cause of why some pwME experience severe insomnia that would be a great relief for many. I had a close friend who suffered severe insomnia from day one of post-infectious illness for 18 years.
I don't experience insomnia and getting refreshed sleep will not...
Sars-CoV-2 vaccine-elicited immunity after B cell depletion in Multiple Sclerosis.
"Noravax homologous boosting induced a significantly more robust serological response than mRNA boosting"...
Abstract
Purpose: New-onset chronic musculoskeletal (MSK) pain is one of the common persistent symptoms in Long COVID (LC). This study investigated its clinical characteristics, underlying mechanisms, and impact on function, psychological health, and quality of life.
Patients and methods: 30...
Exclusion Criteria
Recognized as a 'severe risk' of experiencing post-exertional malaise following engagement in physical tasks. Determined using the De Paul symptom questionnaire
Why would PEM be listed as an exclusion for this trial?
https://classic.clinicaltrials.gov/ct2/show/NCT05911906
Abstract
Long COVID, as currently defined by the World Health Organization (WHO) and other authorities, is a symptomatic condition that has been shown to affect an estimated 10-30% of non-hospitalized patients after one infection. However, COVID-19 can also cause organ damage in individuals...
Tread on our RCT published in Lancet’s where we show early treatment with 2-drug combos of fluvoxamine, bromhexine, cyproheptadine, niclosamide in COVID
✔ completely prevented deterioration
viral load
inflammatory cytokines
Long Covid risk
Full Title: Early treatment with fluvoxamine, bromhexine, cyproheptadine and niclosamide to prevent clinical deterioration in patients with symptomatic Covid-19: a randomized clinical trial, 2024, Dhammike Leshan Wannigama et al
Summary
Background
Repurposed drugs with host-directed antiviral...
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB1.5 mRNA booster in humans
M. Alejandra Tortoricic; Amin Addetia; Albert J Seo; Jack Brown; Kaiti Sprouse; Jenni Logue; Erica Clark; Nicholas Franko; Helen Chu; David Veesler
Highlights
XBB.1.5 COVID-19 mRNA vaccine...
https://trials.recovercovid.org/autonomic
NIH opens long Covid trials to evaluate treatments for autonomic nervous system dysfunction
Part of NIH’s RECOVER Initiative, trials will test at least three treatments for symptoms such as fast heart rate, dizziness and fatigue...
Highlights•
Isolated mAbs to EBV gp42, which is required for the fusion of the virus to B cells
gp42 mAbs A10 and 4C12 use different mechanisms to inhibit EBV fusion to B cells
Two distinct sites were identified on gp42 for receptor binding and for fusion to B cells
gp42 mAb A10 prevented...
Merged thread
Do people with ME/CFS and joint hypermobility represent a disease subgroup? An analysis using registry data, 2024, Kathleen Mudie et al
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, multifaceted disease that affects millions globally...
Abstract
Background:
Although calcium and vitamin D (CaD) supplementation may affect chronic disease in older women, evidence of long-term effects on health outcomes is limited.
Objective:
To evaluate long-term health outcomes among postmenopausal women in the Women’s Health Initiative CaD...
Background: Coronavirus disease 2019 (COVID-19) features a hypercoagulable state, but therapeutic anticoagulation effectiveness varies with disease severity. We aimed to evaluate the dynamics of the coagulation profile and its association with COVID-19 severity, outcomes, and biomarker...
My daily dose of iron supplementation was 27mg w vitamin C. It took 9 months to bring my ferritin up to 55 from 5 and it would drop back down to 14 within 2 months after I stopped taking iron.
Alternate-day administration of 100 and 200 mg taken from the link posted above would make sense...
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