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I've read Harris book and thought it was really interesting. I've written a blog post many of the examples he discusses (surgical procedures that were commonly performed but shown to be ineffective in randomized controlled trials). The blog post is discussed in this thread...

Would be interesting to hear if anyone knows of other examples in this list - of surgical interventions that were commonly performed and thought to be effective, only to be shown to be useless in randomized controlled trials.

Merged thread The fascinating history of surgery: when placebo-controlled trials clash with common beliefs - ME/CFS Skeptic I've made a new website for my articles and commentaries on ME/CFS research. I've just posted the first new blog post...

Posting this here: Day & Altman. BMJ Statistical Notes. Blinding in clinical trials and other studies, 2000. https://www.bmj.com/content/321/7259/504

News from the European ME Coalition (EMEC): In response to a parliamentary question by Pascal Arimont, the European Commission stated that it is working to address under-investigated conditions, of which ME/CFS is a paradigmatic example, in the first work programme of Horizon Europe. Although...

Quote from the paper: Here's a link to the Family Reported Outcome Measure (FROM‐16): https://www.cardiff.ac.uk/__data/assets/pdf_file/0006/1492323/Family-Reported-Outcome-Measure-FROM-16-English-version.pdf

Raynayd et al. COVID-19-related medical research: a metaresearch and critical appraisal https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-020-01190-w More than half of all papers on COVID-19 did not include any data or analytics (comprising expert opinion pieces).. Original...

Thanks! Looks like CFS was not included in the modelling:

Does anyone have access to this paper?

Thanks for pointing this out. Have corrected this in the original post. Apologies for any confusion!

Just noticed this statement from Moss-Morris on the website of Recovery Norway (my bolding) Rona Moss-Morris, Professor of Psychology as Applied to Medicine, Head of Health Psychology, King’s College, London, UK. Correction: the quote below is actually from Wyller. Thanks to @MSEsperanza for...

I suspect that criteria that are too broad will likely result in null results. As I understand it in most areas of medicine, researchers are usually accused of defining their inclusion criteria too strict; of selecting patients where they think treatment will work. Clinicians than usually reply...

The only randomized trial for patients diagnosed with criteria where PEM is required is the trial by Pinxsterhuis et al. 2015. It tested a self-management program based on the Energy Envelope Theory for ME/CFS patients diagnosed with the Canadian criteria. The intervention did not have any...

Happy new year everyone! I've written a new blog post with an overview of the most interesting findings of ME/CFS research in 2020. https://mecfsskeptic.wordpress.com/2021/01/01/2020-looking-back-at-a-year-of-me-cfs-research/ If you find any errors feel free to post them here and I'll try...

Thanks for posting. If I understand correctly, the quote is from Angela L. Rasmussen, not Eric Topol?

One caveat: although there were few differences for behavioural and psychological measurements at time point 1 (before the EBV-infection) there were a lot of statistically significant differences at time point 2 (during EBV-infection). Those who went on to meet ME/CFS case definitions had more...

Yes I think so, the previous EBV study by Jason and colleagues showed how the percentage of patients meeting ME/CFS criteria declined from 13% at six months to 4% at 24 months. https://pediatrics.aappublications.org/content/124/1/189.short But this doesn't' explain why the rate at six months in...

From the paper:

Looks like an interesting study. Kudos to the research team of Jason who seems to be one of the few who is doing structural research to further develop the field. I wonder how this study relates to their previous one on EBV-infection in students - was there an overlap between these two...