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Absolutely.

But in which case how can it discriminate between ME and other fatiguing illnesses? There must be so many conditions where hand grip strength falls off.

I understand what you mean here, and am sure you are right regarding the delay between cause and effect, a notion I am very familiar with in engineering. But I do wonder if it is a multi-faceted problem, because for my wife, her energy depletion pattern is has at least two apparent modes: As...

In the comments, this captures in a nutshell what excessive exercise can potentially do to pwME - pushing too hard past energy reserves, can shrink those reserves each time you do it, in a vicious downward spiral. Few words, big message.

Presumably there are supposed to be checks and balances in place, but they are clearly useless. Something seems truly rotten in this area of the NHS, and it needs thoroughly sorting. In any other area of society where such orchestrated abuse of parents and their children were found, long prison...

He is the epitome of the sort of person who can fall into a pile of poo and come out smelling of roses.

I think it is "peer" as in peering through rose-tinted spectacles.

In this post https://www.s4me.info/threads/the-me-show-series-two.7873/page-5#post-155154 Dr. Nina Muirhead says that her experience of ME's cognitive issues is akin to concussion ... Dr. Muirhead has ME and is a Dr. and surgeon, so is presumably very well qualified to make that statement. And...

Is there a process where scientists can publish follow up clarifications of earlier work? Or can they just do it anyway?

A penny ha'penny.

Yes, I agree. If you and colleagues cannot fathom that aspect, then further clarification would be good I think.

That would be nice, if it's not breaking some code scientists' code or other.

Much of the paper acknowledges there is still a lot they do not understand, including their statement "This investigation forms part of on-going studies that require further investigation before mechanisms may be suggested with a good degree of certainty." I suspect some of what you do not...

As I write this I see @Simon M has also commented on this. I presume you mean, by electrodes, the two gold layers within the sensor, separated by an oxide layer. The superimposed circuit diagram shows that the two gold layers and sandwiched oxide layer, comprise a capacitor, as well as having...

Maybe this is where the capacitance come in. If the cells have a capacitive characteristic to them, then that may be what they mean when they speak of "membrane capacitance Cm". Capacitors have (virtually) infinite resistance (the real component of impedance), but finite reactance (the imaginary...

In which case I'm out of my depth so don't know.

"The impedance results are integrations of the impedance that are attributed to the media− sensor surface interactions (Zm-s), cell−cell interactions (Zc-c), cell−sensor surface adhesion (Zc-s), impedance of cells (membrane capacitance Cm, cytoplasm conductivity of the cells, σcp), resistance of...

I guess the point is that by looking at the impedance, they are gathering signatures for both the resistive and capacitive (I'm guessing inductance is not an issue here) characteristics, which are presumable (inevitably?) due to different facets of the biology, so better chance of not missing...

Yes, I missed that. But the imaginary component was still non-trivial - else there would have been no point using an oscillatory signal, and could have just measured resistance. But in which case the healthy controls would have been subject to the same measurement artefacts. The fact there is a...

Yes.