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According to this article: Of course, there was a time when peptic ulcers were considered a self-reinforcing product of "emotional stress." That time has passed. Has anyone alerted Sir Simon, I wonder?

I've definitely experienced this at times. For me, it's more or less of a "whooshing" sound that might suggest turbulent blood flow. Some believe that it is caused by high blood pressure in the carotid arteries, perhaps due to plaque buildup there - but I've heard this kind of thing...

In Oscar Wilde's "The Picture of Dorian Gray," Lord Wotton says that he likes to choose his enemies for their good intellects. Unfortunately, even in this regard, it looks like ME patients are once again screwed.

I wonder if you would see signs of hypoxia, like blue lips and fingernail beds, if the blood simply couldn't be delivered in an adequate amount to the smallest vessels - perhaps as a consequence of reduced blood cell deformability, or maybe as an effect of some impairment of nitric oxide's...

Maybe the lower number of citations attributed to biological research is just an indication of the relative difficulty of conducting and publishing such research. Biological research often requires carrying out hundreds, if not thousands, of complex and sensitive experiments that involve...

Thanks! For some reason, I thought the original article was an "abstract" and that the full paper was either behind a paywall or had been embargoed all this time. As you pointed out, the original article looks like it appeared in the "proceedings" of a blood conference. I wonder if this was an...

Any idea why this has a different title, is in a different journal and has one less author than before? The text is also different, though it covers the same ground. Was the original merely an "article," while this is the "paper?"

A couple of years after onset, I had a couple of doctors (gastroenterologists at UCLA) take note of the color of my fingernail beds and ponder their significance. I think my nail beds are somewhat darker and more deeply colored than usual (and perhaps slightly tinged blue). To me, it seems...

My impression is that, if we want to get significantly greater funding in the U.S. than we currently have, then the most effective way to get it is through the political means of lobbying the U.S. Congress. Francis Collins clearly has influence over some discretionary funding - and I appreciate...

Maybe the peaks represent the time when you're most likely to be exposed to some virus that provokes a strong immune response. The early peak might represent when you're in school, while the later one represents when your children are bringing home viruses from school. [The early peak around...

Yes - I think they begin by asking if there are any non-believers present. ;)

FWIW, in the late 1980's I saw a PBS documentary about initial attempts to use interferon as an experimental treatment for cancer. Not long after the infusion, the patient experienced an episode of prolonged, uncontrollable shaking, like you'd get if you were severely cold. It's called "rigor"...

It does seem like this would have been reported previously if it was visible on a routine test. Maybe this is something seen only after the cells exit a narrow channel like a capillary. If the cells are relatively inelastic, perhaps they retain their compressed shape longer after squeezing...

Article in U.S. NEWS & World Report:

It seems from the video of Professor Pariante's talk back in October that IL-6 and IL-10 were already a bit elevated in the patients who went on to develop persistent fatigue, even before they started taking interferon alpha. He draws attention to the fact the the levels of IL-6 and IL-10...

It seems like these findings were foreshadowed by the results of the 2006 Dubbo study, which showed a connection between the apparent severity of the initial infection and the later development of ME. So, the worse/more fatigued you initially feel from the "trigger"/initiation of interferon...

Jethro: "I read up here on these here castle ghosts, and all you gots to do is hold a séance and exorcise the rascals." Miss Jane: "But Jethro, you're not a medium!" Jethro (embarrassed): "I know. I'm a large."

There was another thread where some people, myself included, talked about feeling better after waking up after only a few hours of sleep. I flew across county once and then slept only about 4 hours before I had to get up. When I woke up, I felt way better than usual. It lasted for 6-8 hours, but...

It would seem like a good idea to get and store a blood sample from patients who suddenly feel well. These "well" samples could then be compared to either earlier blood samples taken while ill, or to future blood samples should they relapse. Comparing self-to-self seems like the ultimate...

This study is a thing of beauty - sort of like an elegant ocean liner - deploying a parachute - as it falls from the sky.