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I'm not sure what they mean either, but I suspect it's because this paper is far above my analytical pay grade. Over all, I like the paper. It suffers from being so terribly preliminary, and as the authors mention, small sample sizes, among other things. When you are in uncharted territory...

I think this is always the issue with patient driven research. On the one hand, we want to listen to patients and what they say is important. But on the other hand, well patients say the darndest things. Do we follow up on everything in order to redress the years of ignoring people's lived...

Dr Klimas has shown this in years of her work. I don't have citations to hand, but I remember her speaking about it. This isn't about superior knowledge, but about using the ICD-10 classification of diseases. All medical people who claim to be evidence based have to at least pay lip service...

I've been doing a little bit of pilates as I start to feel better. I have definitely had to learn to sit up again and develop the core strength to do so. I've also been doing foot exercises for ballet dancers. It seems like my feet and more core have gotten the weakest and need the most...

Most of the time when I shower I sit cross legged on the floor of the tub. Sitting that way helps a bit. I can't manage a shower chair as my feet would be lower than the rest of me.

If you have these, then it's obvious something viral is going on no matter what the PCR tests say. There isn't much point in doing a fancy blood test if you have an obvious HSV sore. A clinical diagnosis is sufficient. And I've never heard an ME/CFS specialist say herpes sores have any...

Did these people use any objective measures of fatigue, like actigaphy or even a validated questionnaire like the FUNCAP? 'Cause otherwise this is just a survey of which placebo you like best.

Yes, I was wondering about these weight loss results even for healthy people. I wouldn't expect this intervention to make for weight loss without dietary change, but I think they said the participants did not change their diet. The other disappointing thing is how they reported the body fat...

I am currently doing the Muldowney protocol which is an exercise program for EDS. I don't have EDS, but it's a really gentle exercise and something I can do a couple of days a week. It starts you with 1.5 minutes of exercises and builds up to 3 minutes of an exercise, like a bridge. That's...

This is a terribly embarrassing admission, but even when I was fit and healthy I couldn't do 150 sit ups in one session. And I was proud of how long I spent in the gym! I was watching some silly youtube videos about fitness (since I really miss the gym) and came across one where a young guy...

If you can do all this, are you even sick? Did they mention a drop out rate? I didn't see one.

This exercise program looks shockingly hard- 2 60 minute strength sessions twice a week! Anyone who can do this must be mild to begin with. I wonder how much of the improvement in fatigue was due to weight loss, since they show fatigue to correlate with trunk fat and they go on quite a bit in...

What other isues could these be? I m coming to the end of my knowledge of insuline and sugar absortption. Brain too tied to spell...

And some people will certainly spin it to say see- you're out of shape. Low muscle mass and sedentary behavior means insulin resistance!

I see in the slide on the left that there are three different insulin repsonses. All three rise at the same time, but to different levels, so each group is making a different amount of insulin. Is this to the same stimulus? The green people's sugar is staying high after the insulin secretion...

I would think that low glucose absorption is insulin resistance by another name. Glucose is absorbed into the cell from the bloodstream due to the action of insulin on the glucose receptor- metephor about insulin is the key that unlocks the door to let glucose into the cell. I don't know how...

I don't see if the hypoglycemia here is indicating insulin resistance. Some of these people are making too much insulin (hyperinsulinemic) and that is causing their blood sugars to drop. If they were insulin resistant I would expect hyperinsulinemia to make a normal blood sugar, not a low...

I believe he said glucose went up (at least intitially) as it would in burn victims. I don't think he mentioned insulin resistance specifically... Can you have an increase in serum glucose without insulin resistance, say by increased gluconeogenesis?

We don't think this means that insulin resistance is driving ME/CFS do we? My lipids, liver enzymes and A1C have been normal for lo these many years I've been sick. My lipids are embarrassingly good for someone who lies in bed all day eating cheese...

I've heard a CGM is ore accurate than random fingersticks. How low did your sugar get? (If that's not too personal.)