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In years gone by the extra bits were often double and unfinished, especially if covered by a lining.

It seems more likely that the right idea has simply not been put forward yet. The ideas put forward so far are mostly repetition the established wisdom.

It is sad, but not unexpected, to see the lack of anything actually discovered in this article. It is a bit like a report on a collection of different sized space ships landing in Bridlington. "Scientists speculate that they might be from Mars or Neptune or another solar system (er yes)."...

It reminds me of that extra bit of material attached to a jeans pocket below the stitching that carries on just as two flaps of material going nowhere that slides down next to your leg when you put the jeans on. That seems to be Cochrane now - a continuation that no longer does anything and is...

Actually we do have this in the UK. It is the MRC. To be fair they did just this. Eleanor Riley was charged with asking experts what research was considered worth pursuing and what new avenues were worth looking in to. They identified a genome-wide study and offered funding. The chief reason...

It is a puzzling finding but without knowing how the levels found normally relate to exertion or other 'stress' it is hard to know what to make of it. Hanson is an intelligent investigator and I think this is a useful comment. Unexpected findings are often the most important.

The findings may be the beginning of something important but I think we should not lose sight of just how different it would be for a patient to go through a research procedure from a healthy control. When I started out on the wards I did a project looking at cortisol levels and they went up...

Is it possible that the changes in controls are due to activities that are normally associated with a pleasurable sense of having done a nice bike ride whereas these do not occur in PWME who are just trying not to feel too awful? Maybe eating a big dinner? Having a good long sleep?

Ah but it says (something like):

It just looks like ill-informed speculation with no evidence and a gratuitous remark about withholding vaccines. I am not sure spreading disinformation comes under 'well-intentioned'!

All I can remember about butyrate is that it tastes of pineapple. Maybe the cure for ME is eating pineapple for breakfast. I have not found it helps with Long Covid though.

Fit people go on being ill it seems. Certainly my experience. It may not be directly relevant to ME. I don't seem to have PEM, for instance. But I suspect that there is some common factor involved even if not. Military personnel may be an atypical group but they may also be a useful group to...

He appears to be a sympathetic neurologist in his late sixties with a Mohican haircut. I know nothing of him personally but he doesn't sound particularly BPS. He looks to be a competent neurologist, which sounds what you want. He is also a neurophysiologist so is likely to be reliable at...

The final paragraph of the internet history of the RL Hosp. Integ. Med. says: The thread running through the highs and lows of the last 160 years is not great names, nor even the contribution to the art and science of homeopathy or integrated medicine. The ideal that has sustained the Royal...

Maybe stay focused on getting a diagnosis and politely decline any dubious proposals for treatment.

That does not look at all promising. The royal London Homeopathic Hospital was supposed to have been brought under reliable evidence-based medicine when it changed its name in 2007. Looking at the website for its history and the current staffing and services it looks clear that this never...

I see you found the commercial version - which looked as if it might cost 'an arm and a leg' but at £22 is maybe not so bad!

I have never tried to achieve this but if faced with the problem I would try: 1. Putting the smallest latex glove you can get to fit onto the bad forefoot. It might help to put some tubigrip round the foot first so that there are no places water can trickle under the glove. AND 2. Putting a...

Methinks that the Lady doth 'robust' too much - without giving us any data.

You are right. Probably nothing. Antibody tests at one point in time say very little about one individual for most infectious agents.