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  1. Jonathan Edwards

    Survey analysis of 27 people who recovered from COVID vaccine injury and Long COVID

    An honest attempt at gathering data has to include making sure the results are not misleading. If the basics of scientific method are not clear to you @glennchan you might do well to steer clear of all of this. I suspect pretty much everybody on this forum is going to disregard everything you...
  2. Jonathan Edwards

    Clinician-associated traumatization from difficult medical encounters: Results from a qualitative interview study on the Ehlers-Danlos Syndromes

    I have not gone through the paper in great detail but like Hutan I think there may be problems with it. One thing that is strange is that only one out twenty six cases was male and there is no reason why any genuine EDS group should show that. The major problem I see is that the diagnosis of...
  3. Jonathan Edwards

    Trisha Greenhalgh on ME/CFS and Long Covid

    What TG says in the tweets seems reasonable to me. She is surprised by the lack of literature on microclots if they are an important finding. I don't think the lack. of literature is likely to be due to bias - just scepticism amongst haematologists that there will be anything significant to find.
  4. Jonathan Edwards

    American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis, 1995, Felson et al.

    I have never heard of BMC Rheumatology as a journal. Skimming, this looks like an article pushing a politically correct point about patient symptoms in a common sense vacuum. There is a specific problem with CRP for treatments that lower CRP irrespective of any effect on disease. I doubt that...
  5. Jonathan Edwards

    Article: We Might Have Long Covid All Wrong (covers FND,ME/CFS,includes Sharpe,Garner, Carson and more).

    I think the point is that there is a group of people with striking neurological symptoms like seizures or tremors or twisting movement disorders for whom no structural neurological change can be found who can reasonably be put into a diagnostic category. Maybe it should be called 'people with...
  6. Jonathan Edwards

    Article: We Might Have Long Covid All Wrong (covers FND,ME/CFS,includes Sharpe,Garner, Carson and more).

    FND refers to a real group of people, mostly with seizures and movement disorders. It may be a silly diagnosis but the people and symptoms are real. As far as I know LongCovid bears no resemblance. Shure seems to be well into pottyland disinformation.
  7. Jonathan Edwards

    Causes of death among patients with Chronic Fatigue Syndrome, 2007, Jason et al.

    The mean age of ME/CFS patients dying from heart failure, 58.7 years, was significantly lower than the age of those dying from heart failure in the general US population, 83.1 years I wonder if this corrects for the fact that very few people over 65 appear to admit to having ME/CFS for...
  8. Jonathan Edwards

    Post-COVID exercise intolerance ...associated ... capillary alterations and immune dysregulations in skeletal muscles, 2023, Aschman, Scheibenbogen +

    CD68 is a general macrophage marker. CD169 probably equates to active scavenger macrophages with antigen-presenting capabilities. I am not sure that it tells us more than that macrophages have recently been called in. it may do. I would be interested to know what these muscles look like stained...
  9. Jonathan Edwards

    Is PEM a feature of sarcoidosis?

    Studies of this sort are likely to accrue all sorts of biases in the groups of patients studied, depending on what clinics they were drawn from and on and on... I have never heard of this claim about malaise for 24hrs but it doesn't sound to me particularly suggestive of PEM. If you have an...
  10. Jonathan Edwards

    Woman faked qualifications and worked in uk as a psychiatrist for 20 years

    I worked as a rheumatologist for over thirty years without ever doing an exam in rheumatology - as did we all in 1975. The UK public have always been too trusting I suspect.
  11. Jonathan Edwards

    Internet-delivered [CBT] for chronic fatigue among adolescents with a chronic medical condition, 2023, Nijhof, van de Putte, Knoop et al

    I get the impression that this paper is a bit like a family of stick insects that decided to go for a walk where a group of chameleons had decided to make a stake out.
  12. Jonathan Edwards

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    This looks like serious disinformation from a certain Dr Jennifer Curtin, associated with Kaufman and Chheda?
  13. Jonathan Edwards

    Case report: Treatment of long COVID with a SARS-CoV-2 antiviral and IL-6 blockade in a patient with rheumatoid arthritis and SARS-, Vis. et al. 2022

    I had a quick look. I cannot see how one can really draw any conclusions without any control data. Goodness knows what caused what here.
  14. Jonathan Edwards

    UK: Doctors will be encouraged to issue fewer sick notes

    Simon Wessely might well have something to do with this I guess. The mental health benefits of working in the NHS are so great that everyone is leaving. Redeploying people is surely the business of employers, not doctors. This will be yet another incentive for GPs to quit. It is hard to see how...
  15. Jonathan Edwards

    Why we need a deeper understanding of the pathophysiology of long COVID Iwasaki/Putrino 2023

    We need a deeper understanding because the ideas Iwasaki and Putrino are suggesting are just what anyone could have made up from the start and don't go anywhere. It is a pity that biomedical science now has this parallel empty vessel clanging going on alongside meaningful research.
  16. Jonathan Edwards

    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    In a way yes. I was looking for a metaphor for something that seemed to be useful but at some point imperceptibly became an invisible appendage. I have made jeans in my time, but not for maybe fifty years.
  17. Jonathan Edwards

    Independent advisory group for the full update of the Cochrane review on exercise therapy and ME/CFS (2020), led by Hilda Bastian

    You can get to the bottom of the pocket but there is still some fabric beyond the stitching. I admit that this is a feeble modern example of only about 5mm beyond the pocket. I well remember trousers where the spare was a centimetre or more and got increasingly frayed in the washing machine...
  18. Jonathan Edwards

    Covid-19 vaccines and vaccinations

    Autoimmunity is not generally a risk factor for problems with vaccines as far as I am aware. This article appeared in an obscure journal and may be written by people either with no real expertise or with preconceived ideas. Apart from anything else I am not sure that there is any evidence...
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