Search results

1. Find 27 patients with a diagnosis of FND, a diagnosis of anxiety and who seem to have hypermobility. 2. Find 27 healthy patients without any of these issues 3. Give both groups questionnaires covering somaticisation, anxiety and hypermobility 4. Find that the patient group ticks more boxes...

The elevation of GFAP seems fairly subtle when the mild and moderate/severe participants are combined and compared with unexposed participants and with people with other sorts of injuries. The elevation is much more pronounced in the moderate/severe group. Oddly, the levels in the...

Ah yes, I got confused with the 'Request Permission' heading. Here's information about how they worked out if TBI was present or not: They reviewed medical history data in order to define who had a TBI, so it does seem likely that there was some circularity. A momentary loss of...

:D Did the bonsai enjoy the outing?

We've seen some hints that GFAP may be raised in Long Covid, but it is difficult to disentangle the impact of the acute disease and hospitalisation. The Peluso paper with a good sized cohort seemed to find that GFAP was only elevated early on in PASC: But, did the PASC people actually have long...

This study seems a bit circular. We've seen elsewhere how hard it is to diagnose traumatic brain injury, with cases often only being diagnosed after death. People are often given mental illness diagnoses. Even brain scans don't seem to reliably identify the pathology. In this case, I don't...

This is from a Canadian team, specifically from Edmonton. I've sent them an invitation to join us here, and a query about the y axis scale in Figure 1F.

I agree with both of you. She has said that she recovered a bit, and that gardening then helped her quality of life. A problem is the slipperiness of the word 'recovered' - 'improved' versus 'cured'.

Super, thank you forestglip

It's interesting that serum amyloid A was found to be associated with worse fatigue and joint pain in a small study of Gulf War Illness. And it has been mentioned in relation to the microclots, I think the proponents of the microclot theory have found increased SAA in Long Covid.

So, top row Discovery cohort; bottom row validating cohort. SAA is serum amyloid A, charts on the left. IP-10 charts on the right. R2 aren't amazing, but the relationships look quite convincing. But, look at the scales. What is going on there? In chart D, the LC discovery cohort has levels...

GAL-9 levels A so, first they identified a value of Gal-9 that separated the LC-ME/CFS Discovery cohort from the healthy controls (1725 pg/ml). The 97% sensitivity means that nearly every individual with their LC-ME/CFS label was identified by this cutoff. The 100% specificity means that...

I think there are questions about the definitions used to identify the LC patients with ME/CFS. For example, reference #40 reported the following and its abstract did not mention PEM They report Discovery cohort was 44 LC patients and 24 Recovered Validating cohort was 34 LC patients and 34...

Interesting things to look at

Posts about Stuart Murdoch's book have been moved to Stuart Murdoch (of Belle and Sebastian)

I'm not sure what ANZMES have in mind for a patient registry, but they really do need to be collaborating with Paula Lorgelly. I have been talking with her this year about strengthening the coverage of ME/CFS in the Long Covid registry, so that the registry could work for both Long Covid and...

Yes. The Science for ME forum committee agreed to provide a letter of support. This is an example of the sort of thing the forum can potentially do to assist researchers whose aims align with the forum. We didn't post it on the forum at the time, as it was included in an application for...

Thank you @Nightsong, an interesting read.

I can see it's about a book: Being Ill On Sickness, Care and Abandonment Neil Vickers, Derek Bolton It sounds interesting. Here's one review: I expect it helps to explain the stubborn attractiveness of the psychobehavioural hypothesis and 'functional disease' labels to so many people...

Here's a GWAS for MS that found a genome-wide association with an odds ratio of 1.25. The gene that association was in is the target of an MS drug, so presumably there was a real biological association. What exactly does the odds ratio mean in this context? A person with MS in the sampled...