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  1. Snow Leopard

    Validation of the Severity of ME/CFS by Other Measures than History: Activity Bracelet, CPET, SF-36. van Campen et al, 2020

    I had the same reaction. 8000 steps, wow! 5200 steps is around 4 km! I could do 5000 steps maybe once a week if I were to rest for the next few days!
  2. Snow Leopard

    Towards the unity of pathological and exertional fatigue: A predictive coding model, 2020, Greenhouse-Tucknott et al.

    Our nerves do not function quickly enough for motor control feedback to occur in real-time, hence we have a predictive model of motor control (partially located to the supplementary motor area of the brain). Without this model, we would not be able to precisely control the force and location of...
  3. Snow Leopard

    Towards the unity of pathological and exertional fatigue: A predictive coding model, 2020, Greenhouse-Tucknott et al.

    More on this, one of the models is described here: https://www.frontiersin.org/articles/10.3389/fnhum.2016.00550/full The nonsense is revealed in figure 6 where "prior precision of the homeostatic belief is increased from 1 to 4. As a consequence, when a perturbation occurs at (6), this yields...
  4. Snow Leopard

    Coronavirus - worldwide spread and control

    Yes, it is tricky if the lockdown/social distancing/economic factors are reducing deaths due to other reasons like traffic reduced collisions as you mention. There is no "control" lockdown, that we can see what impact lockdowns have on deaths in the absence of an endemic virus... I agree that...
  5. Snow Leopard

    Towards the unity of pathological and exertional fatigue: A predictive coding model, 2020, Greenhouse-Tucknott et al.

    The stuff you summarised is not controversial, and is considered a key part of our understanding of proprioception as explained: https://en.wikipedia.org/wiki/Efference_copy It is the notions of allostasis (borrowed from Noakes) and the weird attentional feedback loop that leads to an...
  6. Snow Leopard

    Towards the unity of pathological and exertional fatigue: A predictive coding model, 2020, Greenhouse-Tucknott et al.

    I just lost a long detailed reply to this thread, sigh. I'll try to be more concise this time I guess. The author seems to be basing his ideas on this: https://pubmed.ncbi.nlm.nih.gov/22641838/ Overall, the article is poorly focused and has a confused understanding of effort perception...
  7. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    I think it is possible to misinterpret what they are saying. Unless people are physically being turned away or never getting results, there are no functional capacity limits. Note that in the link you provided, they state the local "capacity limit" was 48,000, which was lower than the number of...
  8. Snow Leopard

    Brain inflammation

    I don't entertain the idea that he has changed his opinions since: https://www.researchgate.net/publication/323130400_Fatigue_Is_Associated_With_Altered_Monitoring_and_Preparation_of_Physical_Effort_in_Patients_With_Chronic_Fatigue_Syndrome The whole discussion section simply assumes (as a...
  9. Snow Leopard

    Peter White (ed.) 2005, Biopsychosocial Medicine: An integrated approach to understanding illness

    It's noteworthy that Wessely admitted GET is just another form of CBT. This is obvious to anyone who actually has an understanding of exercise physiology and has looked at the protocol(s), yet many (especially medical practitioners who should know better) think that GET is about exercise and...
  10. Snow Leopard

    BMJ Management of post-acute Covid-19 in primary care, 2020, Greenhalgh et al

    She certainly was. Some of us still remember this paper she co-authored with Wessely, where they promote the idea that the health complaints of a certain demographic (middle class women) should be dismissed by medical practitioners. https://academic.oup.com/bmb/article/69/1/197/523356
  11. Snow Leopard

    Cochrane Exercise Review Withdrawn - Individual Patient Data

    And supervisor for @Hilda Bastian's PhD https://iebh.bond.edu.au/education-services/hdr-students-and-opportunities (completions in 2020)
  12. Snow Leopard

    How ME/CFS Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS Nacul et al 2019

    Glad they published, but I still didn't find this particularly enlightening with regards to any specific hypotheses. The concepts like "aberrant homeostasis" and "multi-spiraling disease course" apply to pretty much all chronic diseases. Doctors have long mistaken lesions (tissue damage) with...
  13. Snow Leopard

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    Perhaps the author was someone who has experience as a staffer for a politician. ;)
  14. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    A key point is that, significant myocarditis or other heart damage (or neurological damage) is not typical in Long-COVID patients either. Without strong (prospective population-based) epidemiological studies of post-viral consequences, it is impossible to form any conclusions. There is an...
  15. Snow Leopard

    Pathogens associated with triggering ME/CFS - discussion thread

    There is a huge range of viral upper respirator tract infections. Some of them are dismissed as mere "colds", but some of those "colds" can give you a month long nasty flu-like illness. Epstein-Barr virus can also cause upper respiratory tract infections too (just FYI).
  16. Snow Leopard

    Dr Ron Davis - Updates on ME/CFS research - September 2019 onwards

    To be honest, those mentions make me feel less confident in the the theory, rather than more confident...
  17. Snow Leopard

    Cognitive Behavioural Therapy for chronic fatigue and CFS: outcomes from a specialist clinic in the UK (2020) Adamson, Wessely, Chalder

    Indeed. Generally speaking, if people were really doing much better and pleased, grateful for the therapy, there would be a much higher followup rate. Publishing clinical data like this is only ever "suggestive" quality evidence, but I'm sure this will be cited as strong evidence for the...
  18. Snow Leopard

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    I'm open to considering splitting. Makes a nice alternative to the lumping of "CFS", "SEID" etc. ;)
  19. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    The "40% of people have innate cellular immunity" is nonsense because it is nonspecific. (and specificity is the fundamental basis of the adaptive immune system!) New York state's confirmed case rate is 2.5%. Claims that seven out of eight people infected have not been tested at all is not...
  20. Snow Leopard

    Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia, da Silveira Alves , 2020

    This isn't a "true association", it's the usual candidate gene association junk. I've never seen a study like this for any disease that wasn't complete trash. (note the only true findings are in rare genetic diseases where they trace the candidate gene heritability with 100% specificity and...
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