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I wonder about the latter point myself. If they had just one patient proof-read such documents, they would be written very differently.

"SARS-CoV-2-specific T cells exhibit phenotypic features of robust helper function, lack of terminal differentiation, and high proliferative potential" https://www.cell.com/action/showPdf?pii=S2666-3791%2820%2930102-6 More evidence that immunity towards SARS-CoV-2 is typical and won't magically...

Given that it was for a single day, I doubt it is generalisable. It's easy to report accurately for a day, but it might become tiresome after the 40th day. I wonder also whether children are going to suffer from greater social-desirability biases (including greater diligence in activity reporting)?

Wow, okay... But then again, by linking that here, you've probably doubled the number of people who will actually read it. ;) It's funny how FOIs and concerns about violating ethics agreements are considered worthwhile in other fields where scientists are practising sloppy science - when those...

Who knows, unless they provide more details. They state that it is based on 1344 samples, but compared to what? Were these in-vitro controls? PCR-confirmed samples of a convenience sample? As such, I don't put much stock in the accuracy of quoted figures unless tested in a large...

The claim is either that they aren't experiencing fatigue (in which case, I'd expect their problems to be lung-related in patients who required ventilation - lung fibrosis for example - this will cause perception of shortness of breath, but won't cause fatigue in itself - there is no shortage of...

I don't really know that much and don't have the energy to explain much. I'm not sure what needs explaining either. A key point is that these are "inwardly rectifying" channels, meaning it is easier for K+ ions to travel into, rather than out of the cell. This means they are meant to be closed...

For the level of detail similar to this study, this involves invasive testing: biopsies. MRI scanning can reveal some information about a limited range of metabolites. Potentially in the future, complicated imaging using a complicated array of molecular tagging - not cheap easy or risk free...

It all depends on what we mean by severe. Being unable to work is considered "severe" for most illnesses, but "moderate" in ME and CFS. What we think of as "severe" - bedbound patients, would indeed not be doing maximal CPETs!!!

There is an initial drop, because the high level of antibodies secreted due to stimulation during the initial acute infection phase is no longer needed. Then the IgG levels move into a maintenance phase.

This is interesting, but still "suggestive" quality evidence. Viruses need selective pressures to mutate, perhaps social distancing measures are causing selection for increased infectivity.

I doubt it. Usually variant strains with mutations in key epitope regions occur once there is strong immunological pressure, basically once a large proportion of the population has prior immunity and the virus has to mutate to survive. Sequencing studies of SARS-2 mostly show genetic drift...

While this study has interesting methodology, it is a pilot study and thus not generalisable. 11 patients and 2970 proteins in the quantification, many of these findings could purely be due to chance. The authors did not mention correcting for multiple comparisons. Secondly, another flaw of...

Even if the hypothetically becomes totally hidden, there are memory B cells that divide over time and mature into antibody secreting plasma-cells, this is how immunity is maintained for years post-infection. Any infection initially serious enough to lead to noticeable symptoms will lead to such...

The key point is that muscular capillary function is not controlled by central nerves like Arteries and veins, but regulated locally to maintain a constant-flow condition (variable pressure). It is already known that KATP channels play a key role. Some more discussion here...

No. Regardless of whether the immune system thinks the bug is gone or not, there will still be IgG floating around (in circulation) due to the prior infection.

Not yet. But the serological tests have around a 90% sensitivity several months down the track. This can be due to, but isn't necessarily due to a lack of antibodies, but a failure of the assay to detect all types of antibodies to the pathogen. When you have thousands of people with an illness...

This model has far too many unverified assumptions to be any more than suggestive. Other models could just have likely predicted or assumed more undetected cases in late Jan/early Feb - not just in the USA, but Europe too. I would consider airports themselves as prime candidates for...

Yes, but this bit still grates for me: There is much we do know, from research on SARS-1, ME and other post-viral illnesses, yet almost everyone is ignorant of this because they never bothered to read the research before SARS-2 and few are bothering to read it even now. COVID-19 is far less...

Pleasantly surprised by those replies, Arvind Joshi in particular...