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SARS-2 can certainly cause serious heart problems in (somewhat) rare cases, but this does not apply to most COVID19 cases...

No. This was coauthored by Audrey Stone, at the University of Texas at Austin. You're thinking of Jon Stone at the University of Edinburgh.

The Goal of this study was to test the "perception-filter model" of medically unexplained symptoms (MUS) in "persistent somatic symptom disorder" (SSD) So while participants reporting a higher level of symptoms did have higher heart rates and lower heart rate variation, this was not due to...

This is a useful introduction to the autonomic facets of exercise, but there is of course more going on with regards to the neurology, muscle physiology and biochemistry resulting from exercise. A key point however is the autonomic responses are reactive and lag behind the increase in central...

I'm not convinced that we'll ever have any sort of clinical clarity, given that people use such words to describe very different things, however I see the objective outcomes as augmenting the descriptions of experiences by patients. This is an interesting point. The differing conceptions of...

This wouldn't be the first self-declared expert to have failed to listen and understand the views of patients and to go on and mischaracterise patient views in scholarly literature. I note this (English) review by Sten Helmfrid and Johan Edsberg...

Open-label...

The key is to use a different approach in development, the unique step being to prune the list of questions on the basis of FACE VALIDITY by patients. Too often the questions are selected by researchers, not patients.

From that paper: Minute ventilation and heart rate decreased during (pre-conditioned) placebo, so basically, the individual expected more oxygen and hypoventilation was the result. But so what? This is a conditioned behaviour, not a physiological response. The author of the editorial also...

I disagree, PLOS One is a reputable journal. But it seems the peer-reviewers for this one happened to be a bit to like-minded.

It doesn't say what the ratio is, unfortunately. Given that this is a pre-print, some things can be updated if we are able to notify the authors!

It is curious that a similar number of new cases per million is leading to Aussies freaking out about a "second wave", but a similar number in Sweden is considered "pandemic is over"!?!

"weak immune activation" leads to a lack of antibodies. I don't think this is the problem at all. I agree the key is to be given to patients early. Given late and it will just contribute to the vascular/clotting problems seen in severe patients.

It is certainly confusing. I had to double check Table 1 to confirm that you were right! The error bars don't suggest statistical significance. The lack of significance is likely due to lack of sample-size and within-group variability.

There is a notable unacknowledged bias in this editorial...

In Australian almost-lockdown, when the only reason you're allowed out of the house is to "exercise", actually resulted in a temporary increase in physical activity, at least among a certain demographic. If you are locking people inside their houses (so to speak), you have to expect a temporary...

The problem with statistical models like this is that they don't tend to replicate. The sample size was decent, but 92 male patients and 63 female patients seems like an odd ratio. On the neuropsychological/cognitive testing, patients had the usual poor reaction times and poorer verbal memory...

Except by patients themselves who don't consider it valid or reliable!

There are two factors affecting sensitivity, the first is variability in sampling procedures and the second is if the test is conducted too late after the individual has started to recover, the viral load can be much lower. https://www.bmj.com/content/bmj/369/bmj.m1808.full.pdf

Exactly. CBT for CFS is quintessential "health psychology".