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A high RER is not enough. RPE could be biased due reporting issues (unfamiliarity with exercise, high RPE baseline), high peak blood lactate could exist earlier than VO2Max if the person has a mitochondrial disease. I agree with the effort criteria of the above study - RER>1.1 and a plateau are...

Ah, the news reports earlier today did not report the actual condition. Transverse myelitis is similar to Guillain Barre Syndrome and sometimes GBS is misdiagnosed as Transverse myelitis or vice versa. https://www.bioscience.org/2004/v9/af/1351/fulltext.php?bframe=tables.htm...

I've commented on failure of both controls and CFS patients failing to reach a true maximal effort before - low peak heart rates for example. I've had a conversation with Max Nelson about this, he believes that it can often be a result of insufficient (or inconsistent across participants)...

From the last author, a recent publication: "Post-exertional malaise in veterans with gulf war illness" https://www.sciencedirect.com/science/article/pii/S0167876019305495 The latter point suggests a heterogeneous group and may go some way in explaining their finding of a low Intraclass...

The adverse reaction has to be in the "serious" category for them to call a halt. It could be a coincidence, e.g. someone suffering from a stroke, or it could be a reaction that is probably associated with the vaccine (Guillain Barre Syndrome). I'm not sure how many people they have enrolled so...

Notably, there was no difference in work rate at the Gas Exchange Threshold (VT1) in the GWS patients, suggesting that CFS and GWS are different! The authors talk about poorer test-retest validity for the workrate at VT1, but they are ignoring the fact (1) the test-retest validity in healthy...

How can they say "there does not appear to be an association" when this hasn't been studied at all?

It's curious that they claim the scale is "valid" without ever testing it for face and content validity by patients. Likewise, construct validity cannot be assumed without utilising objective measures of functioning.

Although partly due to the "weekend effect", Australia reported only 43 new cases on Monday. Total active cases is below 2000 and dropping by ~100 per day. Testing remains high with 437,637 tests in the last week.

Which was an editorial referring to this article: https://www.scielo.br/scielo.php?pid=S0004-282X2020005018101&script=sci_arttext Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital

His recent posts on Twitter put him firmly in the "COVID-19 impact is exaggerated" camp, he thinks there is minimal additional risk sending children back to school in Europe and Africa!

Physical deconditioning follows a logarithmic type trend (with a fractional base) where the "equilibrium" level of conditioning is based on the weekly intensity peaks (muscle strength or cardiovascular demand). The initial deconditioning does occur fairly quickly, within a few weeks but slows...

Yes, affordable and widely available for the rest of the world (Asia, South America)! Compared to Remdesivir which costs over $5000 and doesn't save lives...

I think something similar is going on in Sweden - the statistics are being filtered and released occasionally in batches.

Bardsen's study was published in 2016: Heat shock proteins and chronic fatigue in primary Sjögren’s syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804286/ Notably, Yves Jammes has found lower levels of certain HSPs post-exercise in CFS patients in multiple studies...

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 https://www.nature.com/articles/s41590-020-0782-6 Notably: This contradicts the suggestion by Mateus et al. and Grifoni, A. et al. who suggested there was partial T-cell...

Indeed, Gregory Dore's lack of understanding of the "stigma" of longcovid is notable, given that he is a colleague of Andrew Lloyd at UNSW (and regular coauthor).

Starting at 4 hours per day, increasing by 10% every two weeks, and in a year they'll be doing an impressive 48 hours of high energy activity per day! ;) Seriously though, an increase of 20% per week means reaching the 8 hour target in 4 weeks. An increase of 10% per fortnight means reaching...

It does not cease to surprise me how some people keep trying every sort of rationalisation they can think of, to believe that COVID19 is less devastating than official numbers report. The same sort of people on Twitter deny that longcovid is severely disabling, or insist it is simply due to...

No direct relevance to ME in my opinion. The hypothesis isn't really that "new", I remember it being proposed on Twitter back in March and hypotheses published in April and May: https://www.bmj.com/content/368/bmj.m810/rr-35 (March comment) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267506/...