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  1. Mij

    A preliminary study of phosphodiesterases and adenylyl cyclase signaling pathway on red blood cell deformability of sickle cell pts,2023, Evrim Goksel

    Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the mechanical obstruction of the microcirculation by poorly deformable red blood cells (RBCs). RBC deformability is a key...
  2. Mij

    Proximal immune-epithelial progenitor interactions drive chronic tissue sequelae post COVID-19, 2023, Harish Narasimhan et al

    Abstract The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune...
  3. Mij

    Impaired parasympathetic function in long-COVID postural orthostatic tachycardia syndrome – a case-control study, 2023, Stefano Rigo et al

    Abstract Purpose Eighty percent of patients infected by SARS-CoV-2 report persistence of one symptom beyond the 4-week convalescent period. Those with orthostatic tachycardia and orthostatic symptoms mimicking postural tachycardia syndrome, they are defined as Long-COVID POTS [LCP]. This...
  4. Mij

    Long Covid in the media and social media 2023

    Dr. Leana Wen who was a regular commentator on CNN compared wearing masks to every day risks, such as falls, car accidents or drowning started easing her precautions on wearing masks last year when she decided not to put her children's childhood 'on hold' in an effort to eliminate all risks...
  5. Mij

    WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome, 2023 Hwang et al

    My stamina has stayed around the same in the last 23 years of M.E. A viral infection and added menopause has lowered it a bit, which is a normal response for normal people too. I definitely can not increase my activity levels or PEM sets in.
  6. Mij

    Autoimmune encephalitis in COVID-19 patients: a systematic review of case reports and case series, 2023, Hua Xue et al

    Background: There is mounting evidence suggesting that autoimmune encephalitis (AE) can be observed as a neurological complication in patients with COVID-19. This review aimed to summarize the clinical manifestations, types, and outcomes of COVID-19-associated AE. Methods: A systematic search...
  7. Mij

    Accuracy of respiratory gas variables, substrate, and energy use from 15 CPET systems during simulated and human exercise, 2023, Bas Van Hooren

    Abstract Purpose Various systems are available for cardiopulmonary exercise testing (CPET), but their accuracy remains largely unexplored. We evaluate the accuracy of 15 popular CPET systems to assess respiratory variables, substrate use, and energy expenditure during simulated exercise...
  8. Mij

    Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients

    Abstract Two coronaviruses were isolated from brain material obtained at autopsy from two multiple sclerosis patients. The viruses were neutralized by serum and spinal fluid from these patients. Although most of the population have antibody to these virus isolates, multiple sclerosis patients...
  9. Mij

    Long Covid in the media and social media 2023

    https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2023-09-12/04-COVID-Saydah-508.pdf
  10. Mij

    “Inverse Vaccine” Could Treat Multiple Sclerosis and Range of Other Autoimmune Diseases

    Traditional vaccines work by teaching the immune system to recognize a virus or bacteria that needs to be attacked. Now, researchers at the University of Chicago’s Pritzker School of Molecular Engineering (PME) say they have developed a new vaccine that does just the opposite by removing the...
  11. Mij

    Covid-19 vaccines and vaccinations

    Health Canada approves updated Moderna vaccine for COVID-19 OTTAWA - Health Canada has authorized the use of an updated Moderna vaccine for COVID-19 for all Canadians over the age of six months...
  12. Mij

    Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir, 2023, Yinkai Duan et al

    Abstract Nirmatrelvir is a specific antiviral targeting the main protease (Mpro) of SARS-CoV-2, and has been approved to treat COVID-191,2. As an RNA virus characterized by high mutation rates, whether SARS-CoV-2 will develop resistance to nirmatrelvir is a concern. Our previous studies have...
  13. Mij

    Mild to moderate post-Covid19 alters markers of lymphocyte activation, exhaustion . . . assoc by physical activity-level, 2023, Spolador de Alencar

    Full title: Mild to moderate post-Covid-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity-level- and observational sub-analysis fit- Covid study, 2023, Bruna Spolador de Alencar Silva et al Aim: This study...
  14. Mij

    Review Non-Pharmacological Treatment of Autonomic Dysfunction in Parkinson’s Disease and Other Synucleinopathies, 2023, Palma, Jose-Albertoa;Thijs, Roland

    'Many patients with neurogenic orthostatic hypotension also have hypertension in the supine position. The BP can be extremely labile, resembling a volatile stock market chart.' Abstract Symptoms of autonomic dysfunction are prevalent and can be very debilitating, reducing the quality of life...
  15. Mij

    Association Francaise du Syndrome de Fatigue Chronique, Appelation Internationale: EM/SFC

    Illness is the best thing that ever happened to me, testimony from Jérôme Tennis player, best ranking 15, Jérôme has been ill for more than 10 years. He stopped playing in 2019. He has known for a few months what is wrong with him: he has been diagnosed with chronic fatigue syndrome (ME/CFS)...
  16. Mij

    A 53-year-old Californian man, Armando Ramos, Was Hospitalized Due to Unforeseen Sickness While Traveling to the Philippines

    Could this be a cumulative effect of recovered Covid infections? Makes me wonder if previous infection makes us more vulnerable.
  17. Mij

    A 53-year-old Californian man, Armando Ramos, Was Hospitalized Due to Unforeseen Sickness While Traveling to the Philippines

    Despite having no prior health issues, he began experiencing flu-like symptoms such as fatigue and a sore throat while making funeral arrangements. Five days later, he was urgently admitted to a hospital. Initially, doctors diagnosed Ramos with pneumonia and put him on a ventilator...
  18. Mij

    Why insect-transmitted illnesses are emerging threats in Canada and beyond

    Lyme disease, West Nile, and array of lesser-known infections are on the rise scientists warn When Kathryn McKissock's six-year-old son Cameron didn't feel like playing in his Oshawa, Ont., backyard this summer, she figured he was just tired. Then he spiked a fever, and started burying his head...
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