Background: Epstein–Barr virus (EBV) and human herpesvirus 6 (HHV-6) have been associated with multiple sclerosis (MS). Teriflunomide is an oral disease-modifying therapy approved for treatment of relapsing forms of MS. In the preclinical Theiler’s murine encephalitis virus model of MS, the drug...
A review:
Approximately 70% of relapsing-remitting multiple sclerosis (RRMS) patients will develop secondary progressive multiple sclerosis (SPMS) within 10–15 years. This progression is characterized by a gradual decline in neurological functionality and increasing limitations of daily...
The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs, 2023, Jennifer K Frediani et al
Abstract
Background
Early in the COVID-19 pandemic, peak viral loads coincided with symptom onset. We hypothesized that in a highly...
Abstract
Objective Vaccination reduces the risk of acute COVID-19 in children, but it is less clear whether it protects against long COVID. We estimated vaccine effectiveness (VE) against long COVID in children aged 5 to 17 years.
Methods This retrospective cohort study used data from 17...
Long-term Cardiovascular, Cerebrovascular, and Other Thrombotic Complications in Coronavirus Disease 2019 Survivors: A Retrospective Cohort Study, 2023, Jue Tao Lim et al
Abstract
Background
Growing evidence suggests that some coronavirus disease 2019 (COVID-19) survivors experience a wide...
COVID-19 rampant among musicians despite “end of the pandemic”
A remarkable number of musicians—from Ringo Starr to Harry Styles—have canceled concerts and other appearances in the past year due to acknowledged cases of COVID-19 or, more frequently, due to undisclosed illnesses. While...
Airline executives raise alarm that air traffic controller shortage will continue disruption flights for years.
”It will take five to seven years [of hiring] to break even if all goes well,” Airlines for America chief Nick Calio said at the Global Aerospace Summit held by the US Chamber of...
An outbreak of Covid has been blamed for the third air-traffic control slowdown at London Gatwick so far this month.
Staff sickness in the control tower meant the “flow rate” of flights using the world’s busiest runway was reduced.
Fifty flights to and from the Sussex airport were cancelled or...
There have also been spontaneous remissions for pw/MS, but from I've read is that it occurs in the earlier stages of relapse/onset from early intervention with disease-modifying agents.
Ron Davis believes that ME/CFS can be cured because a few people who were diagnosed with ME/CFS may have had...
Omicron has changed how the virus enters cells. Normally, the virus uses a cellular door called ACE2 and a key called TMPRSS2 to get in. Omicron has learned to pick the lock differently, using another form of ACE2 that's resistant to TMPRSS2.
This allows the variant to enter cells more...
Abstract
Continued high levels spread of SARS-CoV-2 globally enabled accumulation of changes within the Spike glycoprotein, leading to resistance to neutralising antibodies and concomitant changes to entry requirements that increased viral transmission fitness.
Herein, we demonstrate a...
Feinstein also speaks a lot about the potential benefits of CBT and mindfulness for 'fatigue' and how clinicians can over come challenges related to access to psychotherapies so that pts can receive appropriate treatment for fatigue.
Full title:
Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive MS(CogEx): a randomised blinded sham-controlled trial
Summary
Background
Cognitive dysfunction in people with relapsing-remitting multiple sclerosis can improve with cognitive...
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