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Forget hard mode- you can now play these video games on "Long Covid Mode" to experience what patients do “The challenges presented by Long COVID and other invisible post-acute infection syndromes like ME/CFS forced us to find novel means to show people without this experience what it really...

Tetrahydrobiopterin (BH4) is an endogenous cofactor for some enzymatic conversions of essential biomolecules, including nitric oxide, and monoamine neurotransmitters, and for the metabolism of phenylalanine and lipid esters. Over the last decade, BH4 metabolism has emerged as a promising...

Canada:

From Wiki: Tetrahydrobiopterin deficiency (THBD, BH4D) is a rare metabolic disorder that increases the blood levels of phenylalanine. Phenylalanine is an amino acid obtained normally through the diet, but can be harmful if excess levels build up, causing intellectual disability and other serious...

https://www.omfcanada.ngo/genetic-and-metabolic-markers-of-bh4-deficiency-in-long-covid/ We have determined that individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are more likely to have pathogenic variants in BH4 synthesis genes compared to the general population, and we have...

Does elevated levels indicate a deficiency? I seem to recall Ron Davis was investigating deficiencies in BH4.

Former Guess Who drummer on life support, family calls for return to mask requirements at health-care centres. Last month, Vance Masters was at home, on a treadmill, exercising in preparation for his first evening out since the pandemic began. Now, the 77-year-old internationally recognized...

The authors argue that the commonly used terms 'mitochondrial function and mitochondrial dysfunction' do not do justice to the diverse mitochondrial features, activities, functions and behaviours within the cells, and thus call for the field to adopt more specific terminology in the context of...

Here's a clue what some are saying:

And yet here we are in 2023 . . . Summary A 34-year-old man affected by exercise intolerance, mild proximal weakness and severe lactic acidosis is described. Muscle biopsy revealed mitochondrial abnormalities and an increase of cytochrome c oxidase histochemical reaction. Biochemical...

These findings provide further evidence that there might be a correlation between the length of time the virus stays in the body and the risk of long COVID (appendix p 1). Therefore, rapid viral elimination in patients with persistent SARS-CoV-2 virus could be crucial. We summarised the approved...

And sometimes making things appear bigger than they really are attracts funding. Who knows where it will go, but it's better than doing nothing? I no longer get hyped but I appreciate Prusty's passion.

Cross-talk between brain cells and peripheral immune cells can modulate the progression of multiple sclerosis (MS), Mount Sinai researchers have discovered. Their findings reveal a previously unknown way in which the brain and immune system talk to each other and may identify a new therapeutic...

Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK Summary Background A rise in the incidence of some autoimmune disorders has been described. However...

There are studies out that conclude that multiple reinfections can lead to LC and long term organ damage down the road for those who were only mildly affected.

Purpose To evaluate the frequency, duration and patterns of long-term coronavirus disease 2019 (COVID-19) symptoms and to analyse risk factors for long-lasting COVID-19 sequelae among a cohort of hospital employees (HEs). Methods We conducted a survey regarding persistent COVID-19 related...

"We will announce a biomarker for #MECFS and #LongCovid very soon. A very interesting piece of the puzzle to unfold in coming weeks. Knowingly I did not use the word 'Novel Biomarker' as a lot is known about it and that is actually a very good news. Fingers crossed!" March 23, 2023

Findings may aid design of targeted drug delivery into the brain and central nervous system Researchers at the UCLA David Geffen School of Medicine, the Howard Hughes Medical Institute at UCLA and the National Institutes of Health have developed a zebrafish model that provides new insight into...