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  1. Mithriel

    BBC treatable disease mistaken for Alzheimer’s

    Arnie Pye, sadly you are a glaring example of the lie that a simple set of neurological tests shows up every brain disease so anything else is a "software" problem to be treated by CBT. The bulldozer spread of Functional Neurological Disorders will only make this sort of tragedy more common...
  2. Mithriel

    Inflammation in multimorbidity and disability: An integrative review, 2019, Friedman and Shorey

    Inflammation may well be the cause of many disease of ageing. Looks like the BPSers are staking their claim early.
  3. Mithriel

    Positive Psychology; Positive Thinking

    Grumpy old b's won't fill out their forms :)
  4. Mithriel

    MS society funds study of immune system to understand why pregnancy can alleviate autoimmune conditions, possible ME relevances

    I have three children and never felt better when pregnant. (I wasn't diagnosed until during the third). I had preeclampsia with all three as well.
  5. Mithriel

    Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders, Espay et al, 2018

    Reading neurosymptoms.org is horrifying. Stating that all these diseases are caused by the nervous system not working and thinking that is an adequate explanation is breathtaking in its arrogance. Their "positive" signs of FND just mean that there is a set of problems they are misdiagnosing...
  6. Mithriel

    The association of major life events with chronic fatigue, 2019, Schmaling & Patterson

    This may be an example of why we have so much trouble communicating out concerns to medical people. Everything seems so innocuous and reasonable and even a standard part of medicine. I see the point about how looking at joint pain in general rather than specific named diseases could be very...
  7. Mithriel

    A general thread on the PACE trial!

    As people have said before, if you do a trial on how many tall men there are in a group you do not have to see any data to know that changing the definition of tall from 6 foot to 5 foot 9 inches will give a higher number. Changes were made before the figures were unblinded is a nonsequitur and...
  8. Mithriel

    Why we shouldn’t take peer review as the ‘gold standard’ - Washington Post. August 1 2019

    This was a big complaint among the physics community years ago. I do not know if it was ever resolved. They said that new theories were being stifled because they were dismissed by peer reviewers with a vested interest in the old theories.
  9. Mithriel

    Untargeted metabolomics analysis of rat hippocampus subjected to sleep fragmentation, 2019, Shin et al

    We now know that sleep is highly dynamic and highly conserved by evolution so it would not be surprising that disruption of sleep has a profound effect on biochemistry. I expect that many diseases and conditions will turn out to have sleep problems behind them Unfortunately we still don't have...
  10. Mithriel

    National Geographic: Newly discovered organ may be lurking under your skin (pain-sensing glial cells, 2019)

    I think most biologists and doctors are open to there being a lot to learn about anatomy and physiology. The problem in my experience has been received knowledge. Generally good doctors have been taught that emotional problems cause physical dysfunction as a fact. They have all met patients who...
  11. Mithriel

    FDA Approves Pitolisant for Daytime Sleepiness in Patients with Narcolepsy

    Dr Cheney did work on diastolic heart failure in ME. He believed we were protected from needing heart transplants (as happens with systolic heart failure) because we are forced to rest when our heart needs it. Also our brains are fragile so revving them up could damage our brains and our...
  12. Mithriel

    Assessing cellular energy dysfunction in CFS/ME using a commercially available laboratory test, 2019, Morten, Newton et al

    This was Shepherd's rationalisation for the change of name, but it has been years and did not make the slightest bit of difference. It has only added to the confusion of names and loses the association with the WHO listing as neurological. A waste of time, not a single neurologist has said "Oh...
  13. Mithriel

    Protocol: Persistent physical symptoms reduction intervention: a system change and evaluation (PRINCE), 2015 onwards, Chalder, Moss-Morris, et al

    I suspect that some have just latched onto a career cynically but a lot believe their treatment works wonderfully but those pesky patients keep listening to doomsayers and joining organisations or are just too lazy/obstructive/weak to do the work involved.
  14. Mithriel

    Functional Neurological Disorder Responds Favorably to Interdisciplinary Rehabilitation Models, 2019, Jimenez et al

    "Subjective measures included pain-related disability, depression, anxiety, and stress scores, whereas objective measures included physical functioning measures (timed up and go, stair climbing test, and 6-min walk test). Pre-iCPRP and post-iCPRP measures were compared using a paired t-test...
  15. Mithriel

    Activity baseline vs activity ceiling, why concepts and language matter

    If I've got it right, the way we produce energy goes like this. The anaerobic reaction produces pyruvate and when enough accumulates the lactic acid cycle begins which uses oxygen and produces lots of ATP if you are healthy. The anaerobic reaction carries on in the background producing pyruvate...
  16. Mithriel

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    Microbes continuously evolve that is change to gain most at least cost. Hosts can only change slowly so the effects of infection vary. That's why you can suddenly get an epidemic or outbreak. Many disease are more dangerous in adults than children. It was thought that polio was a curse of the...
  17. Mithriel

    Eye movement deficits in ME/CFS and sleep deprivation

    Rvallee, the tear film is part of the focusing system for the eye and is incredibly complex. ME is known to interfere with the tear film so that could be causing some of your problems. Dry eye can actually cause eyes to become very wet because too much of the wrong type of tear is made. If you...
  18. Mithriel

    Adolescent recovery

    It is more likely to be the other way round. If an adolescent is very ill they have support systems in place and can rest (if the medical profession let them). Being mildly affected makes it easy to overdo things all the time. When I became ill at 14 I did not realise that everyone did not...
  19. Mithriel

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    At Incline Village Stephen Strauss got involved because his pet theory was chronic epstein barr virus and he saw this as a classic outbreak that would push his work. When some of the patients proved negative for EBV he was furious. He simply took the definition of chronic EBV, left out that...
  20. Mithriel

    The HOME study - Michael Sharpe s CBT for the elderly

    Relative worked in orthopaedics. Some patients were on the ward for months, 9 or more not being unusual, while they waited to be assigned a social worker. Once the social worker was involved the process went quickly but by then people who came in with mild dementia had become institutionalised...
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