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Sorry if I am too late with this, but it seemed to me when I read it that inclusion of 'treatment' in that first sentence is needed to make the second sentence true. Rvallee expanded on the reasons. So: "Worryingly, not only has the psychological medicine approach failed but its proponents have...

Thanks @forestglip

33. Gold JE, Okyay RA, Licht WE, Hurley DJ. Investigation of long COVID prevalence and its relationship to epstein-barr virus reactivation. Pathogens. (2021) 10:763. doi: 10.3390/PATHOGENS10060763 PubMed Abstract | Crossref Full Text | Google Scholar Forum thread: Investigation of Long COVID...

That's a helpful article, I think. BBC health reporters: Philippa Roxby and Smitha Mundasad Some useful comments from Baroness Finlay; DecodeME was mentioned, with a comment from Chris Ponting. Thanks to the people with ME/CFS who fronted up.

It was paywalled, so I couldn't see how they recruited. But, I thought the assumption that the bias towards recruitment for hypermobility would have crept in was pretty safe. Having read the excerpts, I still think that. These people devised the study thinking that hypermobility was important...

Posts on the UK Delivery Plan have been moved to UK Government ME/CFS Delivery Plan (includes Attitudes and Education Working Group and Living with ME Working Group) and consultation

That material is laughably incorrect in so many ways. And yet I'm sure that they have people beating a path to their door willing to pay plenty in the hope of being cured.

:D exactly.

1. Find 27 patients with a diagnosis of FND, a diagnosis of anxiety and who seem to have hypermobility. 2. Find 27 healthy patients without any of these issues 3. Give both groups questionnaires covering somaticisation, anxiety and hypermobility 4. Find that the patient group ticks more boxes...

The elevation of GFAP seems fairly subtle when the mild and moderate/severe participants are combined and compared with unexposed participants and with people with other sorts of injuries. The elevation is much more pronounced in the moderate/severe group. Oddly, the levels in the...

Ah yes, I got confused with the 'Request Permission' heading. Here's information about how they worked out if TBI was present or not: They reviewed medical history data in order to define who had a TBI, so it does seem likely that there was some circularity. A momentary loss of...

:D Did the bonsai enjoy the outing?

We've seen some hints that GFAP may be raised in Long Covid, but it is difficult to disentangle the impact of the acute disease and hospitalisation. The Peluso paper with a good sized cohort seemed to find that GFAP was only elevated early on in PASC: But, did the PASC people actually have long...

This study seems a bit circular. We've seen elsewhere how hard it is to diagnose traumatic brain injury, with cases often only being diagnosed after death. People are often given mental illness diagnoses. Even brain scans don't seem to reliably identify the pathology. In this case, I don't...

This is from a Canadian team, specifically from Edmonton. I've sent them an invitation to join us here, and a query about the y axis scale in Figure 1F.

I agree with both of you. She has said that she recovered a bit, and that gardening then helped her quality of life. A problem is the slipperiness of the word 'recovered' - 'improved' versus 'cured'.

Super, thank you forestglip

It's interesting that serum amyloid A was found to be associated with worse fatigue and joint pain in a small study of Gulf War Illness. And it has been mentioned in relation to the microclots, I think the proponents of the microclot theory have found increased SAA in Long Covid.

So, top row Discovery cohort; bottom row validating cohort. SAA is serum amyloid A, charts on the left. IP-10 charts on the right. R2 aren't amazing, but the relationships look quite convincing. But, look at the scales. What is going on there? In chart D, the LC discovery cohort has levels...

GAL-9 levels A so, first they identified a value of Gal-9 that separated the LC-ME/CFS Discovery cohort from the healthy controls (1725 pg/ml). The 97% sensitivity means that nearly every individual with their LC-ME/CFS label was identified by this cutoff. The 100% specificity means that...