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Yes, it seems that any sort of neuronal loss can cause cortical thinning - dementia, Parkinsons, aging, brain injury. If the authors think that CFS is a disease only of fatigue and impaired cognition, then the study doesn't tell us much. I don't think we have seen much consistency between...

On another issue - recovery Of the 139 people accepted for the study, 20 were later deemed not suitable due to 'clinical improvement'. That's a 14% natural recovery rate - worth tucking away for when we look at studies of treatments.

Arguably, that is exactly what we have seen, people with different mixes of a range of symptoms. But yes, this study seems to suggest that autoantibodies aren't the cause. Or other large molecules in the blood that can't be rapidly replaced. Is there any way the study's findings could be...

For what it is worth @rvallee, it appears that the very reason that Arroll wrote that 2001 article bleating about his 1999 paper on women getting frightened by media reports about oral contraceptives contributing to deep vein thrombosis, the 'panic-stopping' of oral contraceptives and...

Politicians come and go. But, if big drug companies have a financial reason to not see LC as psychosomatic, that could lead to them being more open to the development of drugs for treatment.

Vaccine as prevention against post-Covid-19 condition Makes me think that the big companies selling covid-19 vaccinations may be allies in getting post-Covid-19 condition accepted as not psychosomatic. Symptomatic acute illness is not necessary for post-Covid-19 condition Symptoms 21/28...

Note - small number of cases. Less than 50% were female.

Another excerpt: Clearly, Arroll knows the difference between audit and research, he just feels that he doesn't need to follow the rules. And this case isn't even in the grey zone. It is research.

Yes, there is. I quoted it above.

Seems worth a closer look. It's a decently sized study that, from the abstract, looks to have been well controlled. A question I have is, if a beneficial effect was only short term, would they have picked it up?

I think it's pretty clearly research. It is aiming to answer a question about treatment efficacy, the researcher had direct contact with the subjects, generating new data as they did so. There was no existing knowledge about the question.

Here's the definition of research, Section 1 of the standards:

Here are the standards that govern health research in NZ https://neac.health.govt.nz/national-ethical-standards/part-two/18-quality-improvement Under 'National Ethical Standards' (they aren't great, but they are something)...

I think this is a point well worth investigating more. I also think that a letter to the funders of this study is another advocacy possibility.

The journal is the Journal of Family Medicine and Primary Care. I thought it might not be a well regarded journal, but it seems to be relatively well known. I didn't see a way to submit comments - has anyone found how that is done?

I still recall Dr Ros Vallings, medical advisor to ANZMES, standing up at an ANZMES annual general meeting reporting on this study and suggesting that those of us with ME/CFS were going to run out of telomere length before other people and so die earlier. There were children with ME/CFS in the...

That's a really interesting comment. So, could it be that this finding says nothing about aging per se, but hints at white blood cells potentially being, on average older in the people with ME/CFS (and/or having sedentary lifestyles or immune challenges)?

Arroll leads a unit that provides education resources for New Zealand GPs. He is very influential in NZ medicine. He and the Royal NZ College of GPs have been aggressively promoting the Lightning Process for years. RNZCGP GoodFellow Unit MedCases CPD Sept 2023: Chronic fatigue...

This is an old study now. Has it been replicated?

This is a study of post-Covid-19 cognitive impairment, so the participants haven't had decades yet.