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I'd require measures of both activity patterns and PEM. We must get away from allowing self-report measures on their own. Apart from any other reason, we need some definitive answers here in order to stop the constant drain of research funds into ever more self-report based studies that...

This.

Some members of one side of my family have an essential tremor, some since childhood, including some of the otherwise healthiest people I know. It often runs in families and I have a mild episodic one too, mainly in the hands and arms, but also sometimes also the head/jaw/tongue. Mine started...

Only if methodological rigour is compulsory. Otherwise this shitfest continues on.

@DMissa Thanks for the extra detail.

The single most important and practically useful advice I have ever heard about assessing any study is identify and test the assumptions underlying it, because that is almost always where they will fail. Go for the assumptions, and you will rarely be wrong, and will save yourself a lot of time...

I think there is often a confusion in research between regulates (controls), and interacts with (affects).

C. Mix of both. D. Don't know. I choose D.

According to the current state of research, psychotherapy and psychosomatic rehabilitation have no curative effect in the treatment of ME/CFS. Nevertheless, we see numerous patients in practices and outpatient clinics who suffer severely as a result of their illness and whose mental well-being...

My first thought too. They could argue that the psycho-social influences become less influential over time with general public exposure and awareness. But that might be a difficult one to run. Could just as easily argue that it gets worse. Even that an essential feature of 'functional'...

It is the arbitrary assigning of causal direction, without adequate testing, that is the rotten heart of psychosomatics.

Only some actors. Some of us have always known there is no causal explanation (thus far).

They do. And yet they persist. :confused:

Nearly four decades after getting sick it is still genuinely extraordinary to me just how unyielding and ferocious the medical profession's resistance is to dealing with this issue.

Yep. Follow the money.

So far this year, Luque has published 58 studies at a rate of one every 37 hours. That kind of rate makes me suspicious. Maybe he is Superman. Or maybe there is another explanation.

We are way past merely unprofessional, and well into questions of basic morality and human decency.

Poor widdle doctor-poos. It must be so stressful having to sell snake-oil to your patients day after day, and being confronted with the inevitable lack of results and pissed off patients. Let's give them all medals for being so brave in the face of hard reality.

Psychosomatic advocates promote correlation when it supports their case. And ignore it when it doesn't. How often do you hear them mentioning this study (on ME/CFS) that reported no correlation between actimeter results and self-report fatigue (for CBT)? Psychological Medicine (2010), 40...

No sure banking on AI to fix this is a safe bet.