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Yes, thanks. After also reading Michael Scott's article and the trial paper on CBT for people with depression and advanced cancer I think this is a trial that is specific for the situation in England, but it also raises highly relevant general questions regarding treatment of mental illness in...

Full text paywalled, but this sci-hub link currently is working for me: https://sci-hub.se/https://doi.org/10.1001/jama.2017.13737

Thanks for your reply, @dave30th . My confusion might be due more to some premises of the three concepts of MUS, CBT and IAPT, all of which I have no real knowledge and have read only few of your previous articles dealing with those issues. I'll try to explain my confusion in portions when I...

Hm, I think it should be emphasized that the quoted study is only about advanced cancer and depression: From the quoted paper's abstract: "Although cognitive-behavioural therapy (CBT) has been shown to be effective for depression in people with cancer, it is unclear whether this is the case...

Trial By Error: CBT Provides No Benefits to Advanced Cancer Patients, Study Finds By David Tuller, DrPH http://www.virology.ws/2020/01/15/trial-by-error-cbt-provides-no-benefits-to-advanced-cancer-patients-study-finds/

The DSQ-SF is freely available at REDCap's (34) shared library: https://redcap.is.depaul.edu/surveys/?s=HCT7J8EWPC Seems to me still far from ideal. I like however that it's really short and simple.

Thanks. I'm relieved to hear that.

Another point I'm wondering about is what reasons people could have to assume the study couldn't be helpful. What are the benefits or possible harms if no clear genetic associations were found? Or if the findings showed genetic associations with mental illnesses, how could such findings be...

I think it could be very helpful if someone were able to answer the concerns expressed in the comments on the Virology Blog article, in particular provide more details about the diagnostic / selection criteria. If these details aren't clear yet (according to the FAQ IOM or CCC or Fukuda (*)...

Great to have this on Virology Blog to reach a larger audience and get feedback from those who are skeptic or hesitant. Thank you @dave30th , @Simon M and all involved. Might also be helpful if someone had the capacities to respond to the comments.

Where / how did you find it?

In the SMC Factsheets and Briefing Notes section they tell me: "Please note that our Factsheets and Briefing Notes have now been retired and are no longer available for viewing or download." Perhaps they have been retired together with Prof Wessely (who isn't on the Board of Trustees anymore)...

Don't know where to put this so just leave it here: Cochrane seeks - Research Integrity Editor https://www.cochrane.org/news/cochrane-seeks-research-integrity-editor

"We are pleased to announce the re-schedule of the 2019 Methods Symposium, which was postponed due to the cancelled 2019 Cochrane Colloquium" Date: Wednesday 5 February 2020 https://methods.cochrane.org/2019-cochrane-methods-symposium Type: Interactive webinar Co-chairs: Professor Julian...

To facilitate retrieving @dave30th 's excellent STAT article on SMILE (I think it's the best and most succinct account of what happened so far) : BMJ should retract flawed research paper on chronic fatigue syndrome by David Tuller, Statnews, Dec 2019...

I think this is a worthwhile discussion. If someone wants to play devil's advocate: Are there reasonable arguments to not fund the study? (Except cost which is a bad argument for PACE defenders.) In which way could the findings be misinterpreted? Of course, the SMC's history shows how...

In skimming-only mode so don't know whether this has been suggested: Will participants be offered support with mailing the samples? Could be relevant for pwME that have no carers or only tiny support. Perhaps local support groups could organize collection of samples. I think it could...

Just saw this thread about the protocol's never ending amendments and thought I'd link here:

It seems that Karla Soares Weiser will speak at the UK CFS/ME Research Collaborative (CMRC) Conference in March: https://www.eventbee.com/v/uk-cfsme-research-collaborative-6th-annual-science-conference/event?eid=105083142&fbclid=IwAR3MOQhE0TjDljSZMVDLKwfN5k102Sf_zzYEsf9n1TANoU_sJ4_wsavZHo8#/tickets

I think it's helpful to be aware that many pwME don't seem to experience PEM (only) as worsening of daily symptoms, but (also) as another category of symptoms. Also, I think, if differentiated from general fatigue, specific fatiguability can be a useful term for some symptoms occuring before...