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  1. John Mac

    BioPsychoSocial back in Disability Benefits Policy - Keep Britain Working Report

    If I was asked what is the one thing that a disabled person needs to be given to return to the job market it would be a crowbar, to crowbar that healthy person out of the chair in that cushy job. Nobody is giving up their cushy job for a disabled person, only the jobs that are physically...
  2. John Mac

    Review Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease, 2025, de Canson et al

    Long COVID is an umbrella term for the heterogeneous long-term consequences of SARS-CoV-2 infection. It encompasses a wide spectrum of phenotypes (sometimes overlapping), and its underlying mechanisms might vary across and within phenotypes. Trials that do not account for this heterogeneity risk...
  3. John Mac

    Review The Clinical Relevance of Mast Cell Activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Rohrhofer et al

    Abstract Background/Objectives: Growing evidence suggests that mast cell activation (MCA) may contribute to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating disorder characterized by persistent fatigue and post-exertional malaise (PEM). Particularly in relation to...
  4. John Mac

    Preprint Virus Genome Sequences in the Blood of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients, 2025, Davis et al

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a baffling disease. The disease has a wide spectrum of severity, to date has no established molecular marker, no known causation, and no cure. Many patients report in retrospect that they suffered a virus infection prior to...
  5. John Mac

    Crowdfunding for David Tuller during October 2025

    $66,920 raised. 98% of target. 533 donors. 13 hours left.
  6. John Mac

    Medscape Article: Research Into ME/CFS Pathology Points to Possible Treatments, Miriam E. Tucker

    New possibilities for the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are emerging as research continues to untangle the complex, multisystem pathophysiology of the two overlapping diseases. At International Association for Chronic Fatigue Syndrome/...
  7. John Mac

    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS (ResetME) - Haukeland University Hospital

    It was showing up as being updated in the last 24 hours so maybe it was just edited.
  8. John Mac

    Reddit - Interesting posts on Reddit, including what some doctors say about ME/CFS

    Why Many ME/CFS ‘Recovery Stories’ Aren’t Recovery Stories at All AI generated content - approach with ⚠️ There is a pattern I see in almost every so-called “recovery” story that makes the rounds online, especially the ones tied to coaching or spiritual rebranding. The illness was never...
  9. John Mac

    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS (ResetME) - Haukeland University Hospital

    Study of Daratumumab Injections for Patients with Moderate to Severe Chronic Fatigue Syndrome What is this study about? This clinical trial is focused on studying the effects of a medication called daratumumab on patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). ME/CFS...
  10. John Mac

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    https://www.icontact-archive.com/archive?c=144836&f=2941&s=6745&m=1196284&t=9e9c98a7d9387eb5c584b7e81a15d03a3040ca2700682dadb514b7c01a8d57f0 Dear Subscriber, In this edition, we reveal that the Timms review will cover existing personal independence payment (PIP) claimants as well as new ones...
  11. John Mac

    Crowdfunding for David Tuller during October 2025

    $54,373 raised 79% of target 420 donors 3 days left https://crowdfund.berkeley.edu/project/47768
  12. John Mac

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Why ME/CFS Biomarker Headlines Keep Failing to Deliver Every few years, headlines appear claiming that scientists have finally found a biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Each time, the community feels a surge of hope: maybe this is it—the long-awaited...
  13. John Mac

    Crowdfunding for David Tuller during October 2025

    $29,246 Raised toward our $68,000 Goal (43%) 18 days left 238 Donors
  14. John Mac

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Cort Johnson's take on the study https://www.healthrising.org/blog/2025/10/17/diagnostic-test-me-cfs-epigenetic/
  15. John Mac

    BBC: Exciting results from blood test for 50 cancers

    A blood test for more than 50 types of cancer could help speed up diagnosis, according to a new study. Results of a trial in North America show that the test was able to identify a wide range of cancers, of which three-quarters don't have any form of screening programme. More than half the...
  16. John Mac

    Crowdfunding for David Tuller during October 2025

    $15,403 22% of total raised so far 152 donors. https://crowdfund.berkeley.edu/project/47768
  17. John Mac

    American College of Sports Medicine’s Guidelines for Exercise Testing

    New CPET Guidelines: What They Mean for People with ME/CFS The American College of Sports Medicine’s Guidelines for Exercise Testing and Prescription, for the first time, includes a section on ME/CFS. ACSM is a leading authority on exercise science, and these guidelines serve as a foundational...
  18. John Mac

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    https://theconversation.com/can-a-new-blood-test-really-detect-me-cfs-an-expert-unpacks-new-research-267099 'Scientists in the United Kingdom say they have developed a blood test that can diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with 96% accuracy – the first of its...
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