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  1. John Mac

    Review Autoantibodies in COVID-19 survivors with post-COVID symptoms: a systematic review, 2024, Notarte et al

    Objective: The long-lasting persistence of autoantibodies stands as one of the hypotheses explaining the multisystemic manifestations seen in individuals with post-COVID-19 condition. The current review offers restricted insights into the persistence of autoantibodies in plasma/serum in people...
  2. John Mac

    Trial Report Long COVID Brain Fog Treatment: Findings from a Pilot Randomized Controlled Trial of Constraint-Induced Cognitive Therapy, 2024, Uswatte et al

    Now published - post with link here Preprint Abstract Purpose: Long COVID brain fog is often disabling. Yet, no empirically-supported treatments exist. This study′s objectives were to evaluate feasibility and efficacy, provisionally, of a new rehabilitation approach, Constraint-Induced...
  3. John Mac

    Preprint Relationship between acute SARS-CoV-2 viral clearance with Long COVID Symptoms: a cohort study, 2024, Herbert et al

    Abstract Introduction: The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. Methods: A total of 7361 asymptomatic community-dwelling people enrolled in the Test Us at Home parent study between October 2021 and February...
  4. John Mac

    The nanoneedle salt stress test – too good a clue to leave abandoned on the lab bench?

    https://meassociation.org.uk/2024/07/professor-robert-dorey-and-colleagues-update-on-investigating-the-electrical-properties-of-blood-from-people-with-me-cfs/ Professor Robert Dorey and colleagues update on investigating the electrical properties of blood from people with ME/CFS July 2, 2024...
  5. John Mac

    Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to Two Years Following COVID-19, 2023, Peluso +

    https://www.sciencemediacentre.org/expert-reaction-to-study-looking-at-t-cell-activation-and-viral-rna-persistence-in-long-covid/ expert reaction to study looking at T cell activation and viral RNA persistence in long Covid Prof Danny Altmann, Professor of Immunology, Imperial College London...
  6. John Mac

    Preprint Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios)

    MEA Comment (Dr Charles Shepherd) Having helped to prepare recommendations on all aspects of hospital management for people with severe and very severe ME/CFS in the 2021 NICE guideline on ME/CFS, it is disappointing to find that there are people with severe ME who are still being very badly...
  7. John Mac

    Preprint Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry, 2024, Pretorius

    Does anyone know if this group have used healthy controls in their previous studies? ETA: I only ask as if they haven't this could be the first evidence that the blood clots seen in the previous studies were not an artefact of the testing process and were genuinely in the patients blood. That...
  8. John Mac

    Refining the search for long-COVID biomarkers

    Thomas Vogl at the Medical University of Vienna, Austria, together with colleagues at the University Medical Center Groningen, the Netherlands, plan to use their Global Grant for Gut Health to identify potential biomarkers for long COVID by screening for antibodies against hundreds of thousands...
  9. John Mac

    Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants 2024 Marshall-Gradisnik

    Widely reported mostly by themselves. Have they reached a dead end with this finding in ME and are now just moving on to new diseases? What next TRMP3 in Lyme disease, TRMP3 in Long Covid?
  10. John Mac

    What can be done to combat CFS/ME?

    A perfect example of garbage in, garbage out. An AI generated response. Insight from top 4 papers To combat Chronic Fatigue Syndrome/Myalgic Encephalitis (CFS/ME), a multi-faceted approach is recommended. Research suggests that a concentrated intervention program involving education, cognitive...
  11. John Mac

    Australia: National Health and Medical Research Council (NHMRC): Development of ME/CFS guidelines

    https://www.medicalrepublic.com.au/new-long-covid-cfs-guidelines-to-drop-graded-exercise-therapy/108489 New guidelines for treating long covid and myalgic encephalomyelitis/chronic fatigue syndrome are to be developed by the National Health and Medical Research Council – but we already know...
  12. John Mac

    Esther Crawley

    A very, very wide spectrum
  13. John Mac

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    Work Capability Assessments to December 2024 https://www.gov.uk/government/statistics/esa-outcomes-of-work-capability-assessments-including-mandatory-reconsiderations-and-appeals-june-2024/esa-work-capability-assessments-mandatory-reconsiderations-and-appeals-june-2024
  14. John Mac

    Trial Report Pro Inflammatory Cytokines Profiles of Patients With Long COVID Differ Between Variant Epochs, Ganesh et al, 2024

    https://pubmed.ncbi.nlm.nih.gov/38808863/ Abstract Background: Over 30% of patients with COVID-19 have persistent symptoms that last beyond 30 days and referred to as Long COVID. Long COVID has been associated with a persistent elevation in peripheral cytokines including interleukin-6...
  15. John Mac

    National Academies: New Report Reviews Evidence on Long COVID Diagnosis, Risk, Symptoms, and Functional Impact for Patients 2024

    https://www.nationalacademies.org/news/2024/06/new-report-reviews-evidence-on-long-covid-diagnosis-risk-symptoms-and-functional-impact-for-patients News Release | June 5, 2024 WASHINGTON — A new report from the National Academies of Sciences, Engineering, and Medicine presents conclusions...
  16. John Mac

    Trial Report Whole blood transcriptome in long-COVID patients reveals association with lung function and immune response, Blankestijn et al, 2024

    Abstract Background Months after infection with SARS-CoV-2, at least 10% of patients still experience complaints. Long-COVID is a heterogeneous disease and clustering efforts revealed multiple phenotypes on a clinical level. However, the molecular pathways underlying long-COVID phenotypes are...
  17. John Mac

    Trial Report A Holistic Analysis of Symptom Profiles among People with Long COVID-19 in India: A Prospective 1-Year Follow-Up Study, Vaishali et al, 2024

    Abstract: Objectives Examining the health of COVID-19 patients after hospitalization, with a focus on monitoring common and incapacitating symptoms at four weeks and a year after discharge, is a seldom investigated topic that may yield important information about long-term consequences. Methods...
  18. John Mac

    The economist: Many mental health conditions have bodily triggers

    The BPS lot will take that as a direct physical threat
  19. John Mac

    Driver's brain fog from covid-19 linked to Cork crash that claimed lives of elderly couple

    And there are plans to force half a million sick people back to work in the UK, how many of them will be suffering from Covid-19? From my own experience at the Job Centre before finally getting ESA bus driver jobs were always being promoted/pushed. 4-30 am starts for a person who struggles to...
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