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  1. John Mac

    Maeve Boothby O'Neill - articles about her life, death and inquest

    Phantom healthcare for ‘real’ diseases: when will ME/CFS and long Covid get parity? Historically, medicine has had a problem with women, especially those who were not married. Sounds unrealistic? The nineteenth century wasn’t that long ago, and many diagnoses and treatments of physical...
  2. John Mac

    Community Matron - Knowsley Long COVID Service

    Job advert on DWP site. Not difficult to see how they view Long Covid. Summary Be responsible for planning, reviewing and renegotiating programmes of care to promote health gains, maximise independence, recovery and reablement within a defined caseload in conjunction with the Long COVID Tier 3...
  3. John Mac

    Trial Report Multi-omics landscapes reveal heterogeneity in long COVID patients characterized with enhanced neutrophil activity, 2024, Jingwen Ai et al

    Abstract Background Omicron variant impacts populations with its rapid contagiousness, and part of patients suffered from persistent symptoms termed as long COVID. The molecular and immune mechanisms of this currently dominant global variant leading to long COVID remain unclear, due to long...
  4. John Mac

    Medscape CPD course: A Fresh Look at ME/CFS: Diagnosis and Management of a Multisystem Illness, Natelson et al.

    Full title: A Fresh Look at Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Diagnosis and Management of a Multisystem Illness Target Audience and Goal Statement This activity is intended for primary care physicians, nurses, nurse practitioners, and other healthcare providers (HCPs)...
  5. John Mac

    Opposite white matter abnormalities in post-infectious vs. gradual onset chronic fatigue syndrome revealed by diffusion MRI, 2024, Yu et al

    Now published - see Post #6 Preprint Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating illness with an unknown pathogenesis. Although post-infectious (PI-ME/CFS) and gradual onset ME/CFS (GO-ME/CFS) manifest similar symptoms, it has long been...
  6. John Mac

    Review Blood Biomarkers of Long COVID: A Systematic Review, 2024, Thomas et al

    Abstract Background: Long coronavirus disease (COVID; LC) affects millions of people worldwide. The exact mechanisms which result in a broad, undulating and detrimental symptom profile remain unknown. Blood biomarkers associated with LC have been described; however, consensus on these remains...
  7. John Mac

    Cardiac Output–Cerebral Blood Flow Relationship Is Abnormal in Most ME/CFS Patients with a Normal Heart Rate & Blood Pressure ..., 2024, van Campen

    Published Link here: Cardiac Output–Cerebral Blood Flow Relationship Is Abnormal in Most ME/CFS Patients with a Normal Heart Rate & Blood Pressure ..., 2024, van Campen Preprint Full title: The cardiac output - cerebral blood flow relation is abnormal in most ME/CFS patients with a normal heart...
  8. John Mac

    Over-representation of Torque Teno Mini Virus 9 (TTMV9) in a Subgroup of Patients with ME/CFS, 2024, Giménez-Orenga, Oltra et al

    Now published Over-Representation of Torque Teno Mini Virus 9 in a Subgroup of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Linked in post below Karen Giménez-Orenga, Eva Martín-Martínez, Elisa Oltra Preprint Abstract Myalgic Encephalomyelitis/Chronic...
  9. John Mac

    Preprint A blood supply pathophysiological microcirculatory mechanism for the Long COVID, 2024, Koutsiaris

    Abstract Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID‑19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements to basic laws. In this work, a common framework for the Long COVID...
  10. John Mac

    Maeve Boothby O'Neill - articles about her life, death and inquest

    I doubt it, they don't like being questioned, they would probably accuse the questioners of being dangerous militants!
  11. John Mac

    Trial Report Inflammation in the COVID-19 airway is due to inhibition of CFTR signaling by the SARS-CoV-2 spike protein, 2024, Pollard et al

    Abstract SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, ENaC, the epithelial sodium channel...
  12. John Mac

    Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. (Widjaja, Cook, et al 2024)

    A drug has increased the lifespans of laboratory animals by nearly 25%, in a discovery scientists hope can slow human ageing too. The treated mice were known as "supermodel grannies" in the lab because of their youthful appearance. They were healthier, stronger and developed fewer cancers than...
  13. John Mac

    Trial Report Inflammatory profiles are associated with long COVID up to 6 months after COVID-19 onset, 2024, Wynberg et al

    Full title: Inflammatory profiles are associated with long COVID up to 6 months after COVID-19 onset: A prospective cohort study of individuals with mild to critical COVID-19 Abstract Background: After initial COVID-19, immune dysregulation may persist and drive post-acute sequelae of COVID-19...
  14. John Mac

    Trial Report Blood Flow To The Head Is Reduced in a Patient With Myalgic Encephalomyelitis With Confirmed Post-Exertional Malaise, 2024, Lee

    N = 1 doesn't "prove" anything. Then why not wait until that study is completed before going public?
  15. John Mac

    Cardiopulmonary and metabolic responses during a 2-day CPET in [ME/CFS]: translating reduced oxygen consumption [...], Keller et al, 2024

    Cort Johnson has an article on the study https://www.healthrising.org/blog/2024/07/10/validated-cpet-energy-chronic-fatigue-syndrome/
  16. John Mac

    Plasma Neurofilament Light Chain: A Potential Biomarker for Neurological Dysfunction in ME/CFS, 2024, Azcue et al

    Full title: Plasma Neurofilament Light Chain: A Potential Biomarker for Neurological Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder characterized by heterogeneous symptoms, which lack...
  17. John Mac

    Apps used by NHS clinics for ME/CFS and Long Covid

    Moved posts to start a new thread to collect discussions of NHS apps Mersey Care's Long Covid Service launches new exercise App for patients Mersey Care’s Long COVID service has developed content for an online app to help speed up the recovery of patients suffering from the effects of the...
  18. John Mac

    Review Potential pathophysiological role of the ion channel TRPM3 in ME/CFS and the therapeutic effect of low-dose naltrexone, 2024, Lohn et al

    Full title: Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with a broad...
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