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Here you go, @Trish. I don't feel at all well enough today to offer a thorough critique, but a few random thoughts: This seems more like an attempt to influence the NICE process rather than being a useful & original contribution to the literature. They seem particularly concerned that the NICE...

bioRxiv preprint: link, PDF Summary SARS-CoV-2 has infected over 160 million and caused more than 3 million deaths to date. Most individuals (>80%) have mild symptoms and recover in the outpatient setting, but detailed studies of immune responses have focused primarily on moderate to severe...

Yes, important to realise that this is not just a random video, but is part of Health Education England's e-learning for NHS clinicians. I asked someone with access to this to find out if there were any other Long COVID or ME/CFS related courses; as shown by the screenshots below, there are...

This programme appears to have been put together back in 2020 and attracted some news coverage at the time (link, link, link). Service evaluation (no control group!): https://www.frontiersin.org/articles/10.3389/fpubh.2021.628333/full

There is an interesting paper in the BMJ (link, main PDF) entitled "Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study" using large coded health records data to estimate the excess risk of developing various conditions in the aftermath of a...

The chapter in question is from "Postural Tachycardia Syndrome: A Concise and Practical Guide to Management and Associated Conditions" (link). I've just skimmed it; here's a sampling: Unfortunately, while there's acknowledgement that PEM can occur in response to exercise, there's no real...

The researchers say that they use a child-centered questionnaire, RCADS in addition to HADS; it appears that this suffers from the same well-known problems as HADS. The RCADS47 can be found here and the scoring can be found here. Almost all pwME are going to answer "often" or "always" to...

https://www.acpjournals.org/do/10.5555/comment1557/abs/ https://www.acpjournals.org/do/10.5555/comment1538/abs/ https://www.acpjournals.org/do/10.5555/comment1529/abs/

Wasn't hopeful that this guidance would change - especially as I'd heard that NHS pain-management clinics had adopted the new approach - but disappointing nonetheless. NICE have set up a false dichotomy with the primary vs. secondary pain concepts; there is little evidence that the conditions...

I've been listening to the video of the Michael Sharpe Swiss Re presentation on Long COVID, and there's a highly disconcerting exchange at the end (transcript and bolding mine): MODERATOR: One last question before we move on to our next speaker is regarding the change in the NICE guidelines...

Haven't read this one thoroughly yet, but attached a copy. Fascinating that the sEMG results in the CFS cohort were the opposite to those expected with disuse (sharp increase in conduction velocity with increasing force indicative of hyperactivated membrane function), and that there was a...

This does not seem to augur well for us, but I may yet be surprised. The draft guideline struck me very much as a closely fought compromise between two warring factions. Undoubtedly there will be many submissions, especially from those whose careers are bound up with the current "services"...

The Journal of a Disappointed Man wasn't Barbellion's only published diary: his diary of his final year of life (1918-1919) was published posthumously as "A Last Diary", and is also well worth a read; I find it difficult to read books on screen, but I think you can find free PDF copies of both...

Now at 10 days post AZ vaccine. My parents had been vaccinated at our GP surgery & said it was well-organised & the rooms used were close to the entrance, so we didn't bother to take a wheelchair, only to find they'd moved to the other side of the building, which I then had to walk - huge...

The link is broken in the handbook, but it's section 6.3.2.

https://gdt.gradepro.org/app/handbook/handbook.html#h.33qgws879zw https://gdt.gradepro.org/app/handbook/handbook.html#h.qmsmbyw3yxsl

I suspect those inclined to the current approach will diagnose more pwME with fibromyalgia; the new NICE chronic pain draft gives them carte blanche to take a thoroughly BPS approach. Alternatively, they could add a diagnosis of a "somatoform disorder", adopt Fink's "bodily distress syndrome"...

Busse and Guyatt's interest clearly goes beyond the application of GRADE - they were, in 2008, described in this paper as members of a "Medically Unexplained Syndromes Study Group".

There's some discussion of the current treatment of "long COVID" in one of the latest videos in the Royal Society of Medicine's COVID-19 series: The discussion turns from the treatment of acute COVID to long COVID in the 31st minute. Dr Glynne (general medicine, UCL) discusses some of the...

The only thing I'd add is that, these days, if a GP - or even a consultant - isn't sure how to treat or refer, they'll often consult one of the subscription-based online resources that produces short actionable summaries of the most recent guidelines. One of the most popular, Medscape's...