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Might be suffering from PFS. Perpetual Fad Syndrome.

Nobody is rejecting n=1 anecdotal evidence out of hand. What is being rejected is that such evidence is a sufficient basis for recommending any treatment to other patients, without robust clinical trials. Particularly from the safety angle. There is no short cut to good evidence, and effective...

For some patients, at least. Not suggesting it happens to all patients.

I don't think they intend harm, as such, just that it takes a distant second place to their self-interest. One of the most powerful of all. Agreed.

Seems clear to me that simply disappearing the whole ME diagnosis by replacing with a 'functional' diagnosis is now their primary means to avoid accountability and reform, and keep their empires intact. It just proves – as if any more proof were required – that they are utterly shameless and...

If you prefer a lower dose then it usually easy enough to cut tablets in half. Buy some empty gel capsules (enteric coated, white ones), and put half a tablet in one of them. I have done that before when the correct dose tablet was temporarily unavailable.

Could also be a stable sub-clinical state, which then gets flipped more or less overnight into a much more serious state by a short term infection, for example. –––––––––– "An increasing number of sexual assaults (SAs) are being reported." Which is a different metric from an increase in...

Trimipramine is no longer available in Australia. Was removed from the approved list last month. https://www.healthdirect.gov.au/medicines/brand/amt,35939011000036105/surmontil

I think this is one of the biggest technical questions about ME: Is there a prodromal phase, where the disease process is in place and actively affecting patients' lives, but is still at the relatively mild end of the spectrum, and the symptom expression is not yet sufficiently distinct to allow...

If I could go back and change the course of history I would stop Covid and LC from ever happening. On the other hand, it has probably been a serious boost for progress on ME, both technical and ethical. So there's that silver lining.

Cargo cult.

One thing that gives me hope is that a paradigm change is rarely a gradual smooth linear thing. The situation looks more or less static for a long time, then a critical mass is reached and over a (relatively) short period the whole situation changes. With a bit of luck, the sort of thing that...

To develop better quality evidence about T&CMs for CFS, future studies should employ more objective diagnosis standards and outcome measurements, larger sample size, and better bias control, and ensure the compliance with the corresponding reporting guidelines. That is how it is done.

Yeah, interesting how the psychosocial crowd only seem to worry about iatrogenic danger with biomedical explanations, never with the psychosocial ones. There is definitely a big psychosocial component to our problems, but it is with how we are viewed and treated by the advocates of psychosocial...

might be an association Does this even justify further research? :bored:

When accusation becomes confession.

I am a strong supporter of free speech. But my hard earned cynicism says that what at least some of the signatories really want is the right to lie and defame with impunity, which is not a right I support in any form. Even the USA recognises that free speech is not an absolute right, that it...

I don't know if ME can exist without PEM. I do know that it is such a common feature of ME, and a distinct phenomenon in its own right, that it must be controlled for in any studies and assessments.

whereas the ratings, algorithm, signalling questions and guidance built into the RoB 2 tool made it easier to work through complexity and context. So, more wriggle and less rigour? (EDIT: Not suggesting that complexity and context don't matter.)

Can't access the full article, but I hope they used a dummy filter arm as well. That would provide a clear answer either way.