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Yes, these are NDE values in the units measured for gamma glutamyltransferase (U/l) and are not Z-scores. See above. Thank you.

Not at all, we were not clear. For each trait (e.g. Chylomicron concentration) we have estimated the Natural Direct Effect (NDE) and it is this that we are plotting here, not the Z-score. And because this trait (Concentration_of_Chylomicrons_and_XL_VLDL) is measured in mmol/litre...

In DecodeME we see a female/male ratio of 5-to-1 (https://openresearch.nihr.ac.uk/articles/3-20), and across all ICD10 G93.3 codes in England we see a ratio of 4-to-1 (https://www.medrxiv.org/content/10.1101/2024.01.31.24302070v1). As these are for UK populations and count >17,000 cases, I do...

Copied post In DecodeME we see a female/male ratio of 5-to-1 (https://openresearch.nihr.ac.uk/articles/3-20), and across all ICD10 G93.3 codes in England we see a ratio of 4-to-1 (https://www.medrxiv.org/content/10.1101/2024.01.31.24302070v1). As these are for UK populations and count >17,000...

As an author, I'd really welcome any suggestions that might improve how this paper describes the science - including, for example, citations in the Introduction. We'd like to improve it before it is submitted to a journal for peer review. Please do email me, but my apologies in advance if I...

Hello all. Here's a new PPI opportunity to be involved in a short-term project: Project Description: Our project aims to investigate the predictive power of various molecular biomarkers and other non-molecular data for detecting ME/CFS and differentiating it from conditions with similar...

Thank you @Andy . A request for 2 PPI members: · ME/CFS-related Immune Research Project based at Imperial College. Proposal not currently funded · Looking to recruit 2 PPI members · Level of engagement: This is for an initial scoping call. If the grant is awarded then...

Thanks. We've looked in UK Biobank data and don't see low alkaline phosphatase levels on average. If anything it might be slightly higher.

Next steps for genetics are: (1) Replication in an independent cohort, (2) Joining forces with other projects to do a meta-analysis and (3) Sequencing whole genomes, looking for rare variants (GWAS only find associations to variants that are frequent in the population). Indeed, there is no...

Variant rs10191329 (minor allele frequency 17%) near to genes DYSF and ZNF638: p = 9.7x10-9 (whereas the usual significance threshold is p<5x10-8). This was then replicated (p=3.6x10-9). Effect size = 0.89 (0.015 standard error). Probably acts on dysferlin (DYSF) but could [also] be on ZNF638...

We still need many more people. In part this is because we don't receive samples for all people sent a kit. The rate of sample kit returns is excellent (85%) - reflecting the strong commitment of pwME - but this does mean that we need to over-recruit to get to our target.

Unfortunately, when we asked 23andMe for their help (using their date), the male PDE10A signal did not replicate. So we need to look again once we have DNA data from DecodeME. (Also for completeness, note that the FinnGen paper finds no genome-wide significant associations for N=7563 cases for...

And a (time-limited) link to the published version of this blog is here: https://authors.elsevier.com/a/1fFlT_KDvPN8-W

I asked Douglas Kell about this striking elevated level of % Area Amyloid for type 2 diabetes (relative to controls). He agreed that they had seen this effect for type 2 diabetes and that this means that a metric of “preformed amyloid microclots” cannot - taken in isolation - be diagnostic of...

Hi Jonathan. I asked Doug Kell about this specifically, and he said that the experimentalists were blinded to case/control status.

Joshua, Simon and I also wrote a slightly more accessible version which is available here: https://www.dropbox.com/s/w8lifiejqc6ovmv/Genetic%20Risk%20Factors%20of%20ME.pdf?dl=0

There are so many people who made today's announcement the success that it has been, esp @Andy @Simon M Sonya, the charities, the funders and our comms/marketing partners. There will be many obstacles to overcome on this 4 year journey. But the best bit about today - for me - was that I now know...

Thanks. I don't think this was replicated by Jackie Cliff et al. : https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full

The Editor would request proof that these SNPs are not associated. Trying to prove a negative is a fool's errand! I do hope that the MEBiomed GWAS is funded. For its objectivity, statistical power and cohort data it is sorely needed.

An infectious onset is not reported for this UK Biobank cohort. Nevertheless, I would expect these SNPs to skew towards zero. But they do not. Genetics is most powerful an instrument when it is applied evenly across the human genome without prejudice as to what could be relevant to ME. Otherwise...