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https://www.scmp.com/news/china/society/article/3076334/coronavirus-strange-pneumonia-seen-lombardy-november-leading https://www.scmp.com/news/china/science/article/3076792/italian-professor-repeats-warning-coronavirus-may-have-spread

Moving on to the consensus part of the article:

The first case in Italy was identified on the 21st of February. Now investigators say it appears that at this point there were already 1200 cases in the Lombardy region. There also was already some excess mortality in January. The virus appears to have circulated in Italy for over a month...

@Snow Leopard what name would you choose?

In my opinion Jasons's argument is flawed because he operationalized PEM incorrectly when assessing the IOM criteria, and then found that there are problems. He claims this is due to lack of exclusionary conditions. I think it's because he misunderstands PEM. He also claims that the core...

That argument doesn't really make sense. What is meant with bias is presumably unrealistic positivity that is detached from reality, and only serves to create hope in the patients. A bit like what is done in LP. If that would translate into truly positive changes for patients, the effects would...

It barely mentions ME/CFS. It would have been an opportunity help doctors understand how to recognize PEM and OI. These are part of more definite syndromes.

How it describes the illness I like what I'm seeing in this document. There seems to be a minor error however.

Ignoring the usual issues with lack of blinding and subjective outcomes, the absence of a no-treatment group at an eventual long term follow up would mean it becomes impossible to tell whether LP is any better than doing nothing in the long term.

Presumbly they will compare the first group to second group, after the first has received LP and while the second is still untreated. In this case, it would effectively be an uncontrolled study.

Is anything known about the study design? If the study is competently designed it could indeed settle the controversy. Unfortunately I suspect that competent researchers would not take LP seriously in the first place or decide to spend time and resources on testing whether you can wish...

An illness that causes reduced exertion tolerance would lead to affected people often saying they did too much or worked too hard. That can be misinterpreted as patients having a certain personality. If a certain kind of patient is more likely to have negative encounters with doctors, that can...

My every day fatigue and weakness is hard to describe but I'm tempted to say it feels like some sort of impairing, sedating poison. I sometimes described it like that even before the whole "something in the blood" idea became popular. It's not a pure fatigue signal, but mixed in there are also...

So my flavour of ME/CFS doesn't seem to involve motor centers. I asked because sometimes it feels like I can't exert force with a limb and that the problem obviously can't be the muscle per se because it worked fine not long ago. It's similar to how one can lack strength in the morning after...

I did have stiffness and brisk knee reflexes (according to a neurologist) for some time during and after the POTS onset. I looked up what brisk reflexes meant and it can mean demyelination. In practice it meant I could not move my legs and feet in the same way as I would before while walking...

It is so strange to believe in psychosomatics. Freud said he had figured out hysteria over a century ago and that he knew how to cure it. Why are all these cures not materializing? A century is plenty of time to refine and perfect the therapy.

What does fatigue and weakness caused by problems with the brain's motor centers feel like? Assuming that this causes these symptoms.

It's not possible to tell from this observation if her behaviour played any role in getting ME. It could have made no difference as well. I think there is the human tendency to look for explanations and speculate about ways a disease could have been averted because it's unpleasant to think that...

Psychosomatics has replaced religion as thing people turn to when there is no hope left. What they have in common is that they both promise you'll be cured if you become a better person. The reality is that getting ill had very little or nothing to do with being a bad person. We just like to...

So all these studies of white blood cell energy metabolism are like the man searching for his keys under the lamp post because it's easier to see there? Speaking of the liver, this organ has not gotten much attention despite being a possible suspect.