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Widespread reports of harms need to be taken seriously even if they aren't obtained from a clinical trial. Clinical trials cannot be assumed to accurately replicate what happens in clinical practice. The investigators may also be hiding the harm in ways that cannot be discovered with published...

Chalder is such a fraud and apparently not many are even noticing. I feel sorry for students who are dragged into this fantasy world.

When I read this, I remembered that Karl Morten has collected metabolomics data on patients doing GET and he said there was a decline in energy metabolism. He showed some of this data at a conference and I understand it will eventually be published. Maybe @Andy knows more. I remember this was...

This and the Edzard Ernst blog shows why The Lancet needs to acknowledge the problems with PACE. People continue to be misled.

This smells like garbage. There is no chance my cognitive problems are due to lack of effort and I highly doubt it's any different with other patients and similar illnesses.

Lombardy may be in the beginning of its second wave. PS: here is a link to an English article https://www.aa.com.tr/en/europe/italy-reports-85-virus-deaths-lombardy-still-troubling-/1866883

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30136-X/fulltext

Fear of LP yes, because upon saying the magic words "I choose the life I love", unbelievers will explode into a cloud of smoke and a swarm of screeching bats will emerge from it. The sheer amount of posivity is just too much.

It is good that Hilda is approaching this the way she is doing. This will give credibility to the new review. My own conclusion is that a difference of opinion doesn't have the explanatory power to explain what is happening. It looks like the PACE trial authors and some of their allies are...

There is definitely a problem when people from multiple countries very consistently produce junk science and react with hostility to criticism. It's hard to precisely define the boundaries of this problem within research and disciplines. While it's true that the core group of these junk...

It's a sign that the political will to research this problem is growing.

@Joan Crawford thank you this is a great letter!

Here however the effect persists and seems not to diminish over time.

The experiments seem to suggest that the blood factor has an effect on cells for a day or even several days. Edit: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161229/ I'm just realizing it's not actually clear that the effect persisted for six days. That was the duration of the experiment...

I would worry about other kinds of bias, for example in the questionnaires, communication with participants or how researchers will interpret the data. The researchers themselves may be completely unaware of the bias affecting these aspects.

The PACE authors sent the message that they would use their media contacts to depict a withdrawal of the review as Cochrane caving in to irrational activists, thereby causing reputational damage. Maybe a way forward for Cochrane would be think about how to withdraw or change conclusions of the...

Sharpe needs a history lesson if he thinks that not being able to explain illness is unusual. There have been many claims of psychogenic illness that all ended when the biological mechanisms of some at the time unexplainable illness became sufficiently explained. Then proponents of the idea of...

I know this symptom. It's associated with POTS.

Why aren't more psychologists speaking up about the danger of indoctrinating patients to believe they are something which they are not?

Questionnaire self-reported childhood trauma is unreliable. I can't recall the details but I think in one study of depression it was found to not correlate with recorded events and (in another study?) the association (nearly?) disappeared when socioeconomic factors were controlled for. That...