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Let's not go hard on newly ill patients. They're still learning what their illness is like and they may struggling to even accept it as it is.

Will they? Maybe it's time to send a letter. @dave30th @Jonathan Edwards

I didn't read everything The Times wrote yet. Did they properly report on PACE yet?

This doctor presumably thought that pushing the patient into relapses was a form of acclimatization or desensitization. He was confident that he understood the mechanisms that were maintaining the illness.

Someone brought up the possibility of a response by BPS people. I hope it does not happen. I would interpret the absence of a response as sign they don't know what to do as their control is slipping. If they're smart, they know that they'll have to back off eventually. Maybe that moment has...

Wessely: no tweets about DecodeME Sharpe: no tweets either Henrik Vogt: no tweets either Do they practice a biopsychosocial approach that pays attention to all important factors, or do they preach a biopsychosocial approach while practizing psychosomatic reductionism? Not sure who else of the...

Maybe to develop ME/CFS one often needs the right combination of bad things to be present at the same time. Like a certain genetic background, a certain immune background, an infection, and not enough rest. For society to finally take ME/CFS serious there may also need to be the right...

Okay, I understand the nature of the problem then. I'm sure that some clever mathematicians or computer scientists have some idea of how to search for combinations of variants that confer high risk of illness. Computer science is very interested in search problems, which this is.

Can you better explain what you mean? By genetic risk shown by epidemiology, do you mean something like twin studies showing that there is an inherited component? The situation with studies attempting to find the associated genes appears to be one where every group gets different results.

He seems to be increasingly taking the view that this post-covid syndrome is probably often ME/CFS.

I hope this study will demonstrate that the right answer to "medically unexplained symptoms" is research to find the biological basis for them.

It will be so interesting and useful to finally know which of the various hypotheses have a genetic basis. We might also learn something about PEM. Is it more a maintenance process (in muscles, blood vessels, etc) gone wrong, or the brain processing signals badly, or some problem with energy...

At least the newspapers don't quote any of the PACE trial con artists.

Thank you for making this happen. This is the latest sign that the situation is improving for patients. I signed up, but am not in the UK.

I'm not feeling confident, but: EBV infects B cells, SARS-2 can infect T cells? Edit: or is it that both can infect the endothelium?

One possible way the whole thing could fail is by advocates avoiding controversy. If you don't explain to decision makers that so much research into ME/CFS is bad not merely because of a lack of funding, but also because people are uninformed or misinformed, you risk that money will go into...

A depletion of tryptophan and an increase in the kynurenine pathway. That seems part of a normal response to an infection. But maybe, if the metabolic trap hypothesis is correct, and this particular virus provokes a particularly strong activation of the kynurenine pathway, then it could be good...

More evidence that the coronavirus was already circulating in Italy in December. 40 waste water samples from different cities collected between October and February were compared to control waste water samples from June 2019 and earlier. Samples were tested by two different labs using different...

Glia and microglia in particular elaborate pro-inflammatory molecules that play key roles in central nervous system (CNS) disorders from neuropathic pain and epilepsy to neurodegenerative diseases. Microglia respond also to pro-inflammatory signals released from other non-neuronal cells, mainly...

It supposedly reduces chronic pain by acting on mast and glia cells and reducing neuroinflammation. It was listed as one of the first line treatments for neuropathic pain on an Italian website. Most studies seem to be of low quality. One study showed objective evidence of nerve healing. I wasn't...