Search results

Interesting paper Oculomotor Behaviour in Individuals with Long COVID-19, 2024, González-Vides et al. There is some link with the 'Spanish Association of Persistent Covid'

From the abstract, this looks interesting - good sample size, good differentiation between the cohorts, looks like all of the measures are reported and all are significantly different and in the same direction. The controls are older (mean age 53.5 years versus 46.4 years in the LC cases)...

Such a good post @Ken Turnbull. I had to do a psychological assessment as part of a recruitment process and some of the questions asked were nonsense and for most, it was obvious what would be a 'wrong' answer, making gaming inevitable. After being offered the job, I mentioned that their...

It's an interesting theory. The previous paper is discussed here:HERV activation segregates ME/CFS from FM and defines a novel nosological entity for patients fulfilling both clinical criteria, 2023, Gimenez-Orenga Of course, a big problem with this study is the size of the samples e.g. only...

Figure 1: a is the responders, b is the non-responders. SF-36 PF

They don't say that SF-36 was the primary outcome. A lot (really a lot) of other things were measured too, e.g. Fatigue Severity Scale, Bell score, PEM-DSQ. It's looking as though the assessment point was actually 4 weeks after treatment. An assessment period that short is especially prone to...

Please can they blind these future studies? Two thirds of patients improving from 25 to 60 on the SF-36 PF score over 6 months in a small unblinded study is interesting, but still within the bounds of a placebo response.

The discussion on the effects of steroid treatments on ME/CFS has been moved to Corticosteroids, hydrocortisone, prednisone for ME/CFS

So many reasons why the Laren et al review is flawed

Very interesting excerpts @ME/CFS Skeptic Yes, certainly a very bad argument. I feel sorry for the PhD student. He drew a logical scientifically valid conclusion but it seems that he was led by his supervisors to exchange it for an unsupportable position. It is an argument we have seen...

The first sentence of the paragraph cites the DSM5-TR. That is the Diagnostic and Statistical Manual of Mental Disorders. In that manual, Functional Neurological Disorder has 'Conversion Disorder' in brackets after it. The list of diagnostic criteria in Box 1 is cited as also being from the...

But I reckon even that paragraph is full of problems. FND is not when the medical and neurologic symptoms fail to match existing medical or neurological conditions. It is when doctors believe that the symptoms don't match existing conditions or other physical conditions that may be identified...

I think the paper usefully makes the point that FND equals hysteria and conversion disorder and mental illness, a That may have some people who have gladly accepted their FND label thinking again. But, it notes that it has been said that a label of FND can be helpful, and does not really...

Yes, but it works against us if the holes in the paper are big enough to drive a truck through. If a patient takes this paper to their GP and says 'look, I don't have FND! because I get dizziness and Table 1 says that people with FND don't', or 'look, I don't have FND! because I have Raynaud's'...

You make a lot of good points Trish, and yes, it looks as though the authors have put a lot of time into the paper, but I agree with Jonathan that it is unfortunately counter-productive. I don't think the paper should be used in advocacy. But that is essentially what the authors say. And, as...

The fact that ME/CFS (and Long Covid) looks different to functional seizures and functional motor disorders doesn't prove that ME/CFS (and Long Covid) aren't also functional disorders. Functional seizures and functional motor disorders present very differently from each other too. The...

Primary author Todd Davenport, senior author Sarah Tyson (sorry for edits)

We have moved some posts directly relevant to managing feeding problems and Jonathan's Qeios article here: Management of Nutritional Failure in People with Severe ME/CFS: Review of the Case for Supplementing NICE Guideline NG206, 2024, Edwards (Qeios) We have moved some posts more directly...

I'm no expert of course, but I think the process of digestion which is noted above to include some molecule synthesis could in fact take more than some minutes. If you think about the post-Christmas dinner effect, people are not leaping about feeling full of energy immediately after consuming a...